Research Peptide & Molecule Glossary

Research Context Overview

This glossary is intended to make it easier for researchers to navigate the terminology that appears throughout our catalog. Instead of listing short, isolated definitions, it brings a bit more context—how certain peptides relate to cell signaling, why some molecules are grouped together, and where they tend to appear in metabolic or molecular workflows. Many of the terms are used repeatedly across different areas of laboratory science, so this page serves as a practical reference point.

All compounds mentioned here are provided for research use only and are handled exclusively within controlled laboratory settings.

Peptide Research — Definition and Scope

In experimental biology, peptides are often examined as short amino-acid sequences that act as signaling cues inside living systems. When researchers synthesize these sequences in a controlled environment, they can observe how each peptide interacts with receptors, how it influences downstream pathways, or how it modifies the flow of intracellular communication.

A number of laboratory groups work with synthetic peptides to approximate native signaling patterns or to study how slight variations in sequence may affect cellular behavior. These investigations shed light on timing, feedback, and receptor sensitivity—details that are difficult to capture with broader biochemical tools. Because peptides bind selectively, they are frequently chosen for studies that require clearly defined engagement with a particular biological target.

Peptides vs. Small Molecules in Experimental Use

Peptides and small molecules are both widely used in research, but the reasons for selecting one over the other can differ considerably.

Peptides
Short chains, usually 2–50 amino acids in length, are selected when a study depends on targeted signaling or precise receptor interaction. Their structure allows for high specificity, which can be useful when a project seeks to isolate the behavior of a single pathway.

Small Molecules
These compact compounds interact easily with enzymes, metabolic processes, and cellular machinery. Because they move more freely across membranes and remain stable under a wider range of conditions, small molecules are often preferred for studies involving metabolism, mitochondrial dynamics, or broad pathway mapping.

Understanding the strengths of each category helps researchers design experiments that align with the goals of functional genomics, cellular engineering, or metabolic investigation.

Applications in Longevity and Metabolic Research

Within longevity studies and metabolic modeling, both peptides and small molecules play practical roles. Researchers use them to observe shifts in cellular energy production, explore oxidative balance, or study how signaling pathways respond under controlled stress conditions.

Some peptides are used in GLP-1–related signaling models or mitochondrial research, while small molecules may be selected to study antioxidant activity or lipid oxidation patterns. Together, these tools help establish clearer laboratory models of cellular adaptation and long-term biological behavior.

Using This Glossary

Each entry on this page includes:

  • a short scientific explanation of the compound,

  • notes on its classification or pathway relevance,

  • a link to the matching catalog item, and

  • references to related long-form content when available.

The aim is to provide a reference that works equally well for quick clarification or more detailed review.

All items described here are intended strictly for research purposes and are used exclusively within professional laboratory environments.

Retatrutide – GLP-1/GIP/Glucagon Triple Agonist Research Peptide

Retatrutide is an investigational peptide that acts as a triple agonist at the GLP-1, GIP and glucagon receptors. In preclinical and early clinical research, this combined receptor profile has been used to explore how simultaneous modulation of incretin and glucagon signalling affects energy balance, glucose metabolism and body-weight regulation. Retatrutide is of particular interest in studies that compare single, dual and triple agonist approaches within the broader incretin field.

NAD+ – Nicotinamide Adenine Dinucleotide

NAD+ is an oxidized coenzyme found in all living cells and is essential for redox reactions involved in energy metabolism. It participates in electron transfer processes within mitochondrial pathways and serves as a substrate for NAD+-dependent enzymes, including sirtuins and PARPs. In research environments, NAD+ is frequently used to study cellular energy turnover, aging-related biochemical changes, DNA repair dynamics, and stress adaptation mechanisms. Its central role in oxidative phosphorylation and metabolic signalling makes it a valuable compound in models examining mitochondrial efficiency and intracellular redox balance.

L-Glutathione (GSH) – Reduced Tripeptide Antioxidant

L-Glutathione (GSH) is a reduced tripeptide comprised of glutamate, cysteine and glycine. It is one of the most abundant intracellular antioxidants and plays a central role in maintaining the redox state of the cell. Research applications focus on glutathione’s ability to neutralize reactive oxygen species, regenerate oxidized biomolecules, and participate in detoxification pathways via glutathione peroxidases and transferases. GSH is frequently used in models studying oxidative stress, mitochondrial dysfunction, redox cycling and xenobiotic metabolism. Its tight relationship with cellular resilience makes it a key molecule in biochemical and metabolic investigations.

SLU-PP-332 – Experimental β-Adrenergic Research Compound

SLU-PP-332 is an experimental research compound explored for its influence on β-adrenergic receptor signalling pathways. Preclinical studies often employ SLU-PP-332 in models assessing metabolic rate, thermogenic activation, adrenergic stress responses and energy expenditure. Although mechanistic data remain limited, the compound is used to investigate how modulation of adrenergic tone may contribute to shifts in substrate utilisation and metabolic homeostasis. Because of its emerging role in metabolic research, SLU-PP-332 is frequently examined alongside incretin and mitochondrial pathways in comparative studies.

5-Amino-1MQ – NNMT Inhibitor for Metabolic Research

5-Amino-1-MQ is a small-molecule research compound studied for its inhibitory effects on nicotinamide N-methyltransferase (NNMT). NNMT plays a role in methylation balance and energy expenditure, and changes in its activity have been observed in models of metabolic dysfunction. Experimental use of 5-Amino-1-MQ focuses on understanding how NNMT inhibition influences cellular NAD+ availability, mitochondrial function and adipocyte metabolism. The compound is commonly included in metabolic and biochemical research frameworks aiming to clarify NNMT-associated signalling pathways.

O-304 (OS-01) – AMPK-Linked Metabolic Modulator

O-304, also referred to as OS-01, is an experimental compound explored in metabolic research for its potential interaction with AMPK-regulated pathways. AMPK is a central energy sensor involved in glucose uptake, mitochondrial biogenesis and cellular stress responses. O-304 is commonly studied in models evaluating thermogenic activation, vascular adaptation and metabolic regulation under energy stress. Due to its broad mechanistic relevance, O-304 is used alongside other metabolic peptides and small molecules to clarify energy balance signalling networks.

SS-31 (Elamipretide) – Mitochondria-Targeted Tetrapeptide

SS-31, also known as elamipretide, is a mitochondria-targeted tetrapeptide that selectively associates with cardiolipin in the inner mitochondrial membrane. Research applications focus on its ability to stabilise mitochondrial structure, influence electron transport efficiency and modulate oxidative stress. SS-31 is frequently used in models examining mitochondrial dysfunction, bioenergetic impairment and cellular resilience under stress conditions. Because of these properties, SS-31 has become a widely used compound in mitochondrial biology studies.

Dihexa – HGF/c-Met Pathway Research Peptide

Dihexa is a synthetic peptide investigated for its interaction with the hepatocyte growth factor (HGF)/c-Met signalling axis. Experimental studies use Dihexa to explore synaptic plasticity, neurotrophic signalling and receptor-mediated pathways that contribute to cellular communication. The peptide is primarily used in neuroscience-oriented models but also appears in broader biochemical investigations related to growth factor signalling.

Bacteriostatic Water

Bacteriostatic water is sterile water containing a small amount of benzyl alcohol, which serves as a bacteriostatic preservative. It is used in laboratory settings as a diluent for preparing research solutions, reconstituting peptides and maintaining sterility during experimental handling. Its extended shelf stability makes it a standard component in labs requiring repeated withdrawals from a single vial.

Histidine Buffered Saline ( HBS )

Histidine-buffered saline is an isotonic solution formulated with histidine to maintain pH stability in experimental systems. It is used in biochemical and cellular research where consistent buffering capacity is required during peptide handling, solution preparation or in vitro assays. Histidine provides a mild, stable buffering range suitable for sensitive compounds.

Phosphate Buffered Saline (PBS)

Phosphate buffered saline (PBS) is an isotonic, non-toxic buffer widely used in biological research. Its balanced salt composition maintains physiological osmolarity and pH, making it suitable for a wide range of procedures including peptide dissolution, cell washing, sample dilution and assay preparation. PBS is considered a core component in molecular biology and peptide research laboratories.