Product Usage: This item is supplied for research purposes only.
Our catalog includes popular compounds such as L-glutathione, NAD +, Retatrutide, Histidine-buffered-saline, SS-31, Bacteriostatic-water, and Phosphate-buffered-saline, all manufactured to the highest purity standards.
Our capsule range is designed for research environments where consistency and ease of use are essential. Each capsule contains a pre-measured amount of compound, reducing preparation variability and supporting reproducible experimental conditions.
Capsule formats are commonly used in studies related to metabolic activity, cellular signaling, and energy-related pathways.
Featured Capsule Compounds
SLU-PP-332 Capsules
Associated with metabolic and cellular adaptation research.
5-Amino-1MQ Capsules
Frequently referenced in NNMT-related metabolic studies.
O-304 and Related Compounds
Used in broader metabolic and signaling-focused experimental models.
Why Capsules Are Used in Research
Delayed-Release Capsule Technology
1. Concept and Principle
A delayed-release capsule is a pharmaceutical or dietary supplement formulation designed so that the active ingredient is released not in the stomach but in a specific segment of the intestinal tract. The delay in release is typically achieved with pH-dependent coatings or special capsule shell technologies.
2. Mechanism of Action
Delayed-release systems most commonly operate on the basis of enteric coatings that resist the acidic environment of the stomach (pH 1–3) but dissolve at the higher pH of the small intestine (pH 5.5–7.5). The most common mechanisms are:
• pH-sensitive polymer coatings (e.g., methacrylic acid copolymers)
• Multi-layered pellet or granule systems inside capsules
• Special HPMC or pullulan capsule shells with modified dissolution
This enables time- and site-controlled release of the active ingredient.
3. Application Objectives
Delayed active-ingredient release serves several strategic purposes:
• Protection of acid-sensitive active ingredients (e.g., probiotics, enzymes)
• Reduction of gastric irritation (e.g., certain minerals)
• Targeted intestinal effect (e.g., microbiome modulation)
• Pharmacokinetic optimization
In dietary supplements it is particularly important for maintaining the stability of probiotics, herbal extracts and bioactive peptides.
4. Technological Solutions
Several technologies can be used to manufacture delayed-release capsules:
4.1 Enteric Coating
The active ingredient in granule or pellet form is coated with a pH-sensitive polymer and then filled into capsules.
4.2 DR Capsule Shell
Special capsules (e.g., DRcaps®, Vcaps® Enteric) provide delayed dissolution on their own, without any separate coating.
4.3 Multi-layered Systems
The active ingredient is built in multiple layers, allowing even complex release profiles.
5. Advantages and Limitations
Advantages:
• Targeted delivery
• Increased stability against acidic environments
• Better tolerability
• Innovative product positioning (especially in premium dietary supplements)
Limitations:
• Higher manufacturing costs
• Technological complexity
• Variability in release depending on individual pH conditions
6. Regulatory and Quality Considerations
In pharmaceutical products, delayed-release formulations must meet strict pharmacopoeial and regulatory requirements (e.g., USP, Ph. Eur.), especially regarding the dissolution profile.
For dietary supplements the emphasis is on stability, proper labelling and actual bioavailability, although regulation is less stringent.
7. Application Examples
• Probiotic capsules (protection against stomach acid)
• Enzyme preparations
• Curcumin or other polyphenols
• Collagen peptides with targeted absorption
8. Summary
Delayed-release capsules play a key role in modern formulation development, especially in the areas of “targeted delivery” and “functional supplementation.” With the right technology choice, the stability and efficacy of the active ingredient can be significantly increased, providing a clear competitive advantage in the premium supplement market.
Quality and Manufacturing
All capsules are produced under controlled European manufacturing conditions and undergo analytical verification to confirm identity and purity.