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Ipamorelin 5 mg – Selective GH Secretagogue Peptide
€90,00
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Overview
Ipamorelin is a synthetic pentapeptide (C₃₈H₄₉N₉O₅; MW 711.9 Da) developed in the 1990s as the first selective growth hormone secretagogue (GHS). It mimics ghrelin to stimulate pulsatile growth hormone (GH) release with high specificity, without affecting other hormones. Studies show its potency in vitro (EC₅₀ 1.3 nmol/L) and in vivo (ED₅₀ 80 nmol/kg in rats, 2 nmol/kg in swine). It has a 2-hour half-life, with peak GH effects at 0.67 hours post-dose, suitable for IV, SC, or intranasal administration. Blends with CJC-1295 or tesamorelin enhance synergistic GH pulses for recovery and optimization.
Mechanism of Action
As a GHS-R1a agonist, ipamorelin binds ghrelin receptors in the pituitary and hypothalamus, activating phospholipase C to raise intracellular calcium and trigger GH secretion from somatotrophs. It inhibits somatostatin, which limits GH release, while boosting IGF-1 levels. Unlike non-selective GHSs, it spares ACTH, cortisol, PRL, FSH, LH, TSH, aldosterone, and acetylcholine, even at high doses. It mimics ghrelin to increase hunger but maintains selectivity. Administration before sleep can induce GH secretion within 20 minutes. In blends like tesamorelin/ipamorelin (6mg/2mg), reconstitution involves 1-2mL bacteriostatic water for dosing (e.g., 0.1mL for 300mcg tesamorelin/100mcg ipamorelin).
Potential Applications
Ipamorelin supports hormonal balance, particularly in women, by restoring fertility, menstrual cycles, and alleviating menopausal symptoms like fatigue, low libido, and weight gain. It increases uterine size and pregnancy rates in infertility cases, and improves thyroid/adrenal function for better energy and mood. For body composition, it reduces fat storage, promotes lean muscle via protein synthesis and satellite cell activation, and enhances strength in aging populations. Anti-aging benefits include collagen production (up to 860% increase), cell repair for skin issues (wrinkles, sagging), and wound healing.
It bolsters bone and joint health by elevating bone mineral content and velocity, countering glucocorticoid-induced loss (e.g., restoring periosteal formation four-fold in rat models). Injury recovery accelerates through tissue repair and reduced inflammation. Metabolic applications involve fat loss via lipolysis, improved insulin sensitivity for blood sugar control, and energy metabolism. It enhances sleep quality (slow-wave sleep), immune function (thymus/T-cell development), brain health (dopamine for Parkinson's), heart function (cardiac output), gastrointestinal motility (for ileus), and sexual health (nitric oxide, testosterone/estrogen boost). In fitness and performance, it's ranked highly among GH peptides for muscle building and recovery, often cycled with other agents such as MK-677 or HGH. Dosing: 100-300mcg/day SC, with blends for glow/skin (e.g., BPC-157/ghk-cu/epitalon) or fat loss. Side effects may include headaches, nausea, flushing, increased appetite, dizziness, joint pain, or hypoglycemia, but it's generally well-tolerated without toxicities. Dosing in clinical settings 100mcg AM, PM (receptor saturation above this dose) Frequently combined with GHRHs like Tesamorelin (300mcg, or CJC-1295 No DAC 100mcg).
For a deeper scientific overview of how GHRP peptides like Ipamorelin differ from GHRH compounds, see our GHRH vs GHRP research comparison. - GHRH vs GHRP research comparison
Product Description – Ipamorelin 5 mg
Synonyms: Ipamorelin, NNC-26-0161, Growth Hormone Secretagogue Pentapeptide
Molecular Formula: C₃₈H₄₉N₉O₅
Molar Mass: ~711.87 g/mol
CAS Number: 170851-70-4
PubChem CID: 9831659
Total Active Ingredient: 5 mg lyophilised peptide per vial
Source: PubChem
Product Usage
This item is supplied for research purposes only.
Peptide Storage
All information provided by PRG is for educational and informational purposes only.
Best Practices for Storing Peptides
To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.
- Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
- Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
- Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.
Preventing Oxidation & Moisture Damage
Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.
- Let the vial warm to room temperature before opening to prevent condensation.
- Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
- Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.
Storing Peptides in Solution
Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.
- If storage in solution is unavoidable, use sterile buffers at pH 5–6.
- Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
- Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.
Containers for Peptide Storage
Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.
- Glass vials: offer clarity, durability, and chemical resistance.
- Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
- Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.
Regenesis Peptide Storage Quick Tips
- Keep peptides in a cold, dry, dark environment
- Avoid repeated freeze–thaw cycles
- Minimize exposure to air
- Protect from light
- Avoid storing in solution long term
- Aliquot peptides to match experimental needs