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5-Amino-1MQ – High Purity Research Molecule (50mg)
€180,00
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5-Amino-1MQ Overview:
5-amino-1MQ is a small-molecule compound that inhibits the enzyme nicotinamide N-methyltransferase (NNMT), a key regulator of energy balance and metabolic processes, particularly active in adipose (fat) tissue. Inhibition of NNMT has been shown to elevate levels of nicotinamide adenine dinucleotide (NAD⁺) — a vital cofactor for cellular metabolism — which in turn can enhance metabolic activity and stimulate the expression of sirtuin-1 (SIRT1).
SIRT1, sometimes referred to as the “longevity gene,” is linked to protective effects against conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis and other cardiovascular diseases, as well as kidney and liver disorders, neurodegeneration, and certain cancers. In preclinical studies, mice given 5-amino-1MQ experienced an average 7% reduction in body mass over 10 days without changes in food intake. Research suggests that lowering NNMT activity may contribute to shrinking fat cells and reducing fat deposit size.
Product Description
Synonyms: 5-amino-1-methylquinolinium, SCHEMBL6403148, CHEMBL4116828, ZINC552049, STL196667
Molar Mass: 159.21 g/mol
CAS Number: 42464-96-0
PubChem ID: 950107
Total Active Ingredient: 6000 mg per container (50 mg per capsule)
Shelf Life: 36 months
What Is 5-Amino-1MQ? - Read More
5-Amino-1MQ Structures
Sources PubChem
5-Amino-1MQ Research:
Research Abstract
There is a critical need for innovative mechanism-of-action approaches to reduce obesity and its related chronic metabolic conditions. Nicotinamide N-methyltransferase (NNMT) has emerged as a novel target, with newly identified roles in cellular metabolism and energy balance.
To validate NNMT as an anti-obesity target, a series of small-molecule NNMT inhibitors were evaluated for membrane permeability, selectivity, mechanism, and physiological effects. The compounds demonstrated strong permeability (via passive and active transport), high selectivity against related methyltransferases and NAD⁺ salvage pathway enzymes, and significant biological activity in cultured adipocytes — reducing intracellular 1-methylnicotinamide (1-MNA), increasing NAD⁺ and S-adenosylmethionine (SAM) levels, and suppressing lipogenesis.
In a proof-of-concept study, a potent NNMT inhibitor administered to diet-induced obese mice significantly lowered body weight, white adipose tissue mass, adipocyte size, and plasma cholesterol, without reducing food intake or causing observable side effects. These results support NNMT inhibition as a promising strategy for reversing diet-induced obesity, with modulation of NAD⁺ and SAM flux likely central to the therapeutic mechanism.
Source: ScienceDirect
Research Information
Obesity is a global public health challenge linked to serious comorbidities such as type 2 diabetes, cardiovascular disease, liver disease, neurodegeneration, and certain cancers. It is characterized by excess fat accumulation and disruption of whole-body energy balance, glucose regulation, hormone function, and lipid metabolism.
Lifestyle interventions such as diet and exercise can improve some obesity-related markers but often fail to achieve sustainable weight loss or glycemic control. Existing pharmacological treatments typically offer limited effectiveness or pose adverse side effects, creating a need for safer and more effective solutions.
NNMT, a cytosolic enzyme, has been identified as a regulator of energy homeostasis through its influence on nicotinamide (NA) and SAM flux within the NAD⁺ salvage pathway and methionine cycle. Elevated NNMT expression is observed in the white adipose tissue of obese and diabetic mice and correlates with increased 1-MNA levels, higher BMI, and larger waist circumference in humans.
Preclinical studies using antisense oligonucleotides to reduce NNMT expression in adipose tissue protected mice from diet-induced obesity and reduced fat mass. Guided by structural modeling, potent methylquinolinium-based NNMT inhibitors were developed with strong membrane permeability and high target selectivity.
In vitro, these inhibitors reduced 1-MNA levels, elevated NAD⁺ and SAM, and suppressed lipogenesis in adipocytes. In vivo, treatment of diet-induced obese mice resulted in reduced body weight, adipose mass, adipocyte size, and plasma cholesterol — without affecting appetite or causing adverse effects. These findings highlight NNMT inhibition as a viable and targeted approach for addressing obesity and its metabolic complications.
Product Usage
This item is supplied for research purposes only.
Peptide Storage
All information provided by PRG is for educational and informational purposes only.
Best Practices for Storing Peptides
To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.
- Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
- Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
- Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.
Preventing Oxidation & Moisture Damage
Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.
- Let the vial warm to room temperature before opening to prevent condensation.
- Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
- Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.
Storing Peptides in Solution
Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.
- If storage in solution is unavoidable, use sterile buffers at pH 5–6.
- Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
- Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.
Containers for Peptide Storage
Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.
- Glass vials: offer clarity, durability, and chemical resistance.
- Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
- Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.
Regenesis Peptide Storage Quick Tips
- Keep peptides in a cold, dry, dark environment
- Avoid repeated freeze–thaw cycles
- Minimize exposure to air
- Protect from light
- Avoid storing in solution long term
- Aliquot peptides to match experimental needs