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CJC-1295 ( No DAC ) 10 mg – High-Purity GHRH Analog Peptide
€110,00
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Overview
CJC-1295 is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) designed to stimulate endogenous growth hormone (GH) production from the pituitary gland. It is available in two main forms: with Drug Affinity Complex (DAC), which significantly extends its half-life, and without DAC, which provides shorter, more pulsatile effects. It is frequently combined with other peptides, such as Ipamorelin, to enhance GH release, improve body composition, support recovery, and promote overall vitality.
Mechanism of Action
CJC-1295 acts as a GHRH receptor agonist, binding to somatotroph cells in the anterior pituitary. This activates G-protein-coupled signaling that elevates intracellular cyclic AMP (cAMP), leading to calcium influx, GH vesicle exocytosis, and increased GH synthesis through transcription factors such as CREB. The result is amplified pulsatile or sustained GH secretion, followed by hepatic production of insulin-like growth factor-1 (IGF-1).
The DAC-conjugated version binds reversibly to albumin, prolonging plasma half-life to approximately 6–8 days. This produces sustained GH elevations (2–10-fold) and IGF-1 increases (1.5–3-fold) that can persist for up to 11 days after a single dose. In contrast, non-DAC CJC-1295 has a shorter half-life (~30 minutes), generating more physiological, pulsatile GH release patterns similar to those seen in younger individuals. Both forms stimulate the GH/IGF-1 axis without introducing exogenous hormones, promoting protein synthesis, lipolysis, collagen production, and cellular repair while preserving natural feedback regulation when dosed appropriately.
Potential Applications
CJC-1295 is primarily used in research and optimization protocols for:
Body composition improvement: Increased lean muscle mass, accelerated fat loss (particularly visceral fat), and enhanced metabolic rate. Recovery and performance: Faster healing from training or injury, improved sleep quality, and greater exercise capacity. Anti-aging and longevity: Counteracting age-related GH decline, supporting connective tissue integrity, reducing inflammation, improving insulin sensitivity, and promoting cardiovascular health. Regenerative therapy: Applications in musculoskeletal repair, metabolic optimization, and addressing conditions associated with low GH/IGF-1, such as sarcopenia or chronic fatigue.
Common protocols involve subcutaneous injection:
DAC version: 100–200 mcg 1–2 times per week for sustained elevation.
Non-DAC version: 100–300 mcg 1–3 times daily (often before bed or post- workout) to mimic natural pulses, frequently cycled 5 days on / 2 days off. Potential side effects include temporary water retention, injection-site reactions, fatigue, or elevated cortisol/prolactin if overdosed. Monitoring and cycling help minimize risks of pituitary desensitization.
Learn more about the role of GHRH analogs such as CJC-1295 in growth hormone research by reading our GHRH vs GHRP overview. - GHRH vs GHRP overview
Product Description:
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molar Mass: ~ 3367.9 g/mol
CAS Number: 863288-34-0
PubChem ID: 56841945
Total Active Ingredient: 10 mg lyophilised peptide per vial
Source: PubChem
Product Usage
This item is supplied for research purposes only.
Peptide Storage
All information provided by PRG is for educational and informational purposes only.
Best Practices for Storing Peptides
To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.
- Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
- Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
- Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.
Preventing Oxidation & Moisture Damage
Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.
- Let the vial warm to room temperature before opening to prevent condensation.
- Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
- Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.
Storing Peptides in Solution
Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.
- If storage in solution is unavoidable, use sterile buffers at pH 5–6.
- Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
- Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.
Containers for Peptide Storage
Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.
- Glass vials: offer clarity, durability, and chemical resistance.
- Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
- Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.
Regenesis Peptide Storage Quick Tips
- Keep peptides in a cold, dry, dark environment
- Avoid repeated freeze–thaw cycles
- Minimize exposure to air
- Protect from light
- Avoid storing in solution long term
- Aliquot peptides to match experimental needs