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L-Glutathione – 3000mg
€70,00
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Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycin.
Glutathione levels decrease with aging, alcohol consumption, environmental factors,
and sleep disturbances. Glutathione oral administration is not effective due to low
bioavailability.
In mitochondria, GSH neutralizes reactive oxygen species (ROS) to prevent
mitochondrial DNA damage and collapse of the mitochondrial membrane potential
below 100 mV.
GSH, by reducing oxidative stress, can improve muscle recovery and reduce fatigue.
An IM protocol used in studies (600 mg every other day for two months) improved
sperm motility and morphology in men with varicocele-related or inflammatory
infertility.
GSH regenerates Vitamins C and E, protects mitochondrial membranes.
If you’re experimenting with mitochondrial agents like SLU-PP-332 and SS-31, GSH
helps you cover the ROS angle.
Glutathione effect boosters in clinical settings:
Vit-D, Selenium 25mcg, L-Glycine 3000mg, NAC 1200mg, Calcium Alpha
Cetoglutarate 300mg, Molybdenum 50 mcg
Detailed description:
At the molecular level, GSH acts as a primary cellular antioxidant by donating
electrons from its thiol group (-SH) in cysteine to neutralize reactive oxygen species
(ROS), such as hydrogen peroxide and superoxide radicals.
Through enzymatic catalysis by glutathione peroxidase (GPx), GSH reduces
hydroperoxides to water or alcohols, forming oxidized glutathione (GSSG) as a
byproduct in the process.
GSSG is then regenerated back to GSH by glutathione reductase (GR), which
utilizes NADPH as a reducing equivalent, maintaining the cellular redox balance.
GSH participates in detoxification by conjugating with xenobiotics and electrophilic
compounds via glutathione S-transferases (GSTs), forming glutathione S-conjugates
that are more water-soluble and easier to excrete.
Non-enzymatically, GSH can directly react with electrophiles, such as lipid peroxides
or reactive nitrogen species, to prevent oxidative damage to proteins, lipids, and
DNA.
In protein glutathionylation, GSH forms mixed disulfides with protein thiols under
oxidative stress, reversibly modifying protein function to protect against irreversible
oxidation.
At the molecular level, GSH supports nutrient metabolism by facilitating the reduction
of dehydroascorbate to ascorbate (vitamin C), thereby recycling this antioxidant.
GSH regulates redox-sensitive transcription factors, such as NF-κB and AP-1, which
are crucial in immune responses and inflammatory processes. Low GSH levels
inhibit T-cell proliferation.
Glutathione Product Description:
Synonyms: γ-L-Glutamyl-L-cysteinylglycine, GSH
Molar Mass: 307.32 g/mol
CAS Number: 70-18-8
PubChem: 124886
Total Amount of the Active Ingredient: 3000mg per serving
Shelf Life: 36 months
Glutathione Structures:
Source: PubChem
Product Usage
This item is supplied for research purposes only.
Peptide Storage
All information provided by PRG is for educational and informational purposes only.
Best Practices for Storing Peptides
To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.
- Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
- Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
- Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.
Preventing Oxidation & Moisture Damage
Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.
- Let the vial warm to room temperature before opening to prevent condensation.
- Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
- Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.
Storing Peptides in Solution
Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.
- If storage in solution is unavoidable, use sterile buffers at pH 5–6.
- Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
- Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.
Containers for Peptide Storage
Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.
- Glass vials: offer clarity, durability, and chemical resistance.
- Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
- Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.
Regenesis Peptide Storage Quick Tips
- Keep peptides in a cold, dry, dark environment
- Avoid repeated freeze–thaw cycles
- Minimize exposure to air
- Protect from light
- Avoid storing in solution long term
- Aliquot peptides to match experimental needs