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Tesamorelin 10 mg – High-Purity GHRH Analog Peptide
€110,00
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Overview
Tesamorelin is a synthetic 44-amino-acid peptide analog of growth hormone-releasing hormone (GHRH), modified with a trans-3-hexenoyl group for enhanced stability and potency. Originally developed as an orphan drug (branded as Egrifta), it received FDA approval in 2010 for reducing excess visceral adipose tissue (VAT) in HIV-infected adults with lipodystrophy associated with antiretroviral therapy. It has since gained attention in anti-aging, body composition optimization, metabolic health, performance enhancement, and cognitive support.
Mechanism of Action
Tesamorelin selectively binds to GHRH receptors on pituitary somatotroph cells, stimulating pulsatile release of endogenous growth hormone (GH) while preserving natural feedback regulation and avoiding receptor desensitization. The resulting GH surge prompts hepatic production of insulin-like growth factor-1 (IGF-1), which promotes lipolysis, protein synthesis, and metabolic efficiency. With a short half-life (8–120 minutes), it mimics physiological GH pulses without significantly affecting cortisol, prolactin, TSH, LH, FSH, or ACTH. It enhances mitochondrial biogenesis, fatty acid beta-oxidation, autophagy, and key signaling pathways including PI3K/AKT/mTOR and AMPK, supporting cellular energy efficiency, myogenesis, and preferential fat utilization. It synergizes effectively with testosterone and other GH secretagogues to amplify anabolism, improve glucose disposal, promote deep sleep, and reduce triglycerides without promoting insulin resistance.
Benefits and Potential Applications
Clinical data demonstrate 12–20% reductions in visceral adipose tissue, 1.3–1.8 cm decreases in waist circumference, and improvements in liver enzymes (reduced ALT/AST) in non-alcoholic fatty liver disease. Lipid profiles improve with significant drops in triglycerides (up to ~150 mg/dL), total cholesterol, and LDL, alongside cardiovascular benefits such as reduced carotid intima-media thickness. Cognitive effects include enhanced executive function, verbal memory, and visual recall, particularly in aging populations or those with mild impairment after 20 weeks of use. For physique and performance, it supports indirect muscle gains through elevated GH, accelerated recovery, increased stamina, and fat loss—most pronounced in caloric surplus (12–20% above maintenance) with optimized testosterone levels. It aids nerve repair, activates satellite cells for myogenesis and angiogenesis, reduces fibrosis during training stress, and improves sleep architecture. Off-label applications include general obesity management, menopausal hormone optimization, immune modulation, sexual function, sleep quality, and athletic performance. Exploratory studies examine its role in age-related abdominal fat accumulation, though long-term safety data remain limited outside the approved indication.
Clinical research settings, dosage and protocols (HED)
Typical dosing is 1–2 mg subcutaneously daily. Common protocols:
0.3-1mg at night (90 minutes after last meal) and 1 mg upon waking for fat loss and body composition. 0.3-1 mg AM and 1 mg PM for men; 1 mg PM only for women. Cycling: 60 days on / 1 week off, or 4–8 weeks on with breaks to minimize antibody formation. Combination: 100 mcg ipamorelin AM (5 days on / 2 off) or rotation with other GHRH/GHRP analogs (e.g., CJC-1295, GHRP-2) to simulate three daily GH pulses (morning, post-workout, bedtime). Reconstitute properly, monitor IGF-1 and glucose periodically.
Side Effects and Precautions
Mild effects include injection-site reactions (redness, swelling, itching in 25–50% of users), myalgia, peripheral edema, pruritus, night sweats, headache, nausea, and transient fatigue.
To better understand how Tesamorelin functions within growth hormone research, explore our detailed guide on the differences between GHRH and GHRP peptides - Differences Between GHRH and GHRP peptides
Product Description – Tesamorelin 10 mg
Molecular Formula: C223H370N72O69S
Total Active Ingredient: 10 mg lyophilised peptide per vial
Source: PubChem
Product Usage
This item is supplied for research purposes only.
Peptide Storage
All information provided by PRG is for educational and informational purposes only.
Best Practices for Storing Peptides
To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.
- Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
- Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
- Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.
Preventing Oxidation & Moisture Damage
Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.
- Let the vial warm to room temperature before opening to prevent condensation.
- Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
- Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.
Storing Peptides in Solution
Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.
- If storage in solution is unavoidable, use sterile buffers at pH 5–6.
- Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
- Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.
Containers for Peptide Storage
Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.
- Glass vials: offer clarity, durability, and chemical resistance.
- Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
- Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.
Regenesis Peptide Storage Quick Tips
- Keep peptides in a cold, dry, dark environment
- Avoid repeated freeze–thaw cycles
- Minimize exposure to air
- Protect from light
- Avoid storing in solution long term
- Aliquot peptides to match experimental needs