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Vial labeled 'SELANK' with PRG logo on a green background
  • Vial labeled 'SELANK' with PRG logo on a green background
  • PRG SELANK 50 mg packaging with a green and white label on a green background
  • Green pen on a white background
Selank 50mg – Research Peptide

Selank 50mg – Research Peptide

€210,00
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Available Research Formats

Introduction

This research-grade peptide is supplied exclusively for laboratory and experimental use. Selank is studied in research models exploring stress regulation, cognitive signaling, and neuroimmune communication. It is commonly examined in experimental systems focused on emotional balance, attention-related pathways, and adaptive neural responses.

Selank is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is an analog of tuftsin, a natural immunomodulatory tetrapeptide derived from the heavy chain of human immunoglobulin G. Selank was created to combine anxiolytic (anti-anxiety), nootropic (cognitive-enhancing), and immunomodulatory properties. It is primarily used in Russia and Ukraine for treating generalized anxiety disorders, neurasthenia, and cognitive impairments. Unlike traditional anxiolytics like benzodiazepines, Selank reportedly lacks sedative effects, addiction potential, or withdrawal symptoms. It is administered intranasally or intravenously, often as a lyophilized powder reconstituted in sterile water, requiring refrigeration for stability.


Chemical Structure


Selank's sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP), a seven-amino-acid chain. The first four residues (Thr-Lys-Pro-Arg) mimic tuftsin, extended by Pro-Gly-Pro to enhance metabolic stability and prolong action.


Mechanism of Action (Molecular Level)


At the molecular level, Selank acts as a positive allosteric modulator of GABA_A receptors, enhancing their affinity for gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter. This modulation inhibits central nervous system excitability, contributing to anxiolytic effects without the side effects of benzodiazepines.

Selank alters gene expression in brain regions like the frontal cortex. In rat models, intranasal administration (300 μg/kg) changes expression of 45 neurotransmission-related genes, with overlaps to GABA's effects. Key alterations include:

- Downregulation of GABA receptor subunits like Gabre (ε, ~20-fold at 1 hour) and Gabrq (θ, ~20-fold at 1 hour), reducing inhibitory tone.

- Upregulation of others like Gabrb3 (β3, 1.58-fold) and Gabrg3 (γ3, 1.29-fold), enhancing receptor function.

 Modulation of dopamine receptors (Drd1a, Drd2, Drd3) was upregulated at 1 hour, and serotonin receptors (Htr3a, Htr1b).

- Downregulation of GABA transporters (Slc32a1, Slc6a1, Slc6a11), prolonging GABA availability.

- Dramatic changes in orexin precursor (Hcrt, ~25-fold downregulation at 1 hour, 128-fold upregulation at 3 hours), aiding sleep-wake regulation.

- Selank elevates brain-derived neurotrophic factor (BDNF) in the hippocampus, promoting neurogenesis, synaptic plasticity, and cognitive function. It modulates monoamine neurotransmitters: enhancing serotonin metabolism (influencing mood, sleep, and appetite) and dopamine release (improving focus and reward).

- As a tuftsin analog, it stimulates interleukin-6 (IL-6) and interferon production, balancing T helper cell cytokines for immunomodulation. Enhance the phagocytic function of macrophages.

- Selank inhibits enkephalin-degrading enzymes, such as carboxypeptidase H, thereby extending the effects of endogenous peptides. It maintains cortisol levels, reducing stress responses.


Pharmacological Effects and Uses


Selank exhibits anxiolytic, antidepressant, and nootropic effects in animal and human studies. It reduces anxiety and asthenia in patients with generalized anxiety disorders, improving emotional stability and cognitive performance.

Nootropic benefits include enhanced memory, concentration, learning, and mental endurance via BDNF upregulation and neural plasticity. It protects against alcohol-induced cognitive deficits by regulating BDNF in the hippocampus and frontal cortex.

Selank, as a tuftsin analog, has neuroprotective and immunomodulatory properties that could theoretically benefit neurodegenerative conditions like ALS, Parkinson’s Disease, and Multiple Sclerosis, which involve motor neuron degeneration, inflammation, and oxidative stress.

Comparative research context:

For a broader comparison of neuropeptide research compounds, including Selank, Semax, and Dihexa, see:
→ Semax vs Selank vs Dihexa – Key research differences

Further research context

For a detailed research-focused overview of Selank, including its molecular structure, neuroregulatory signaling mechanisms, and role in experimental neuroimmune models, see:

→ What is Selank? – A Regulatory Neuropeptide in Experimental Research

Product Description

  • Chemical Formula :  C33H57N11O9
  • Synonyms : Thr-Lys-Pro-Arg-Pro-Gly-Pro, L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-, Selanc, UNII-TS9JR8EP1G
  • Molar Mass : 751.9 g/mol
  • CAS Number : 129954-34-3
  • PubChem : 11765600
  • Total Amount of the Active Ingredient : 50 mg (1 vial)
Selank structures

Source: PubChem
Product Usage

In vitro research or further manufacturing use only. Not for human or animal use.
Peptide Storage

All information provided by PRG is for educational and informational purposes only.

Best Practices for Storing Peptides

To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.

  • Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
  • Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
  • Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.

Preventing Oxidation & Moisture Damage

Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.

  • Let the vial warm to room temperature before opening to prevent condensation.
  • Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
  • Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.


Storing Peptides in Solution

Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.

  • If storage in solution is unavoidable, use sterile buffers at pH 5–6.
  • Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
  • Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.


Containers for Peptide Storage

Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.

  • Glass vials: offer clarity, durability, and chemical resistance.
  • Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
  • Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.


Regenesis Peptide Storage Quick Tips

  • Keep peptides in a cold, dry, dark environment
  • Avoid repeated freeze–thaw cycles
  • Minimize exposure to air
  • Protect from light
  • Avoid storing in solution long term
  • Aliquot peptides to match experimental needs
Logo for 'Verified Purity' with a shield design, molecular symbol, and text indicating European laboratory standard.

Analytical Transparency

All PRG research materials are analytically tested for purity and identity under EU laboratory standards. Manufacturer Certificates of Analysis (COA) are available upon request. If independent third-party analytical testing confirms results consistent with our published specifications, PRG may reimburse the verified laboratory testing cost upon review.

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