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  • EPITHALON packaging with PRG branding on a white background
  • Vial labeled 'Epithalon' with 'PRG PeptideGenesis' on a white background
Epithalon 50mg – High Purity Longevity Research Peptide

Epithalon 50mg – High Purity Longevity Research Peptide

€215,00
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Available Research Formats

Overview


Epithalon (Ala-Glu-Asp-Gly) is a laboratory-synthesized analogue of epithalamin, a naturally occurring peptide secreted by the pineal gland. It has been studied for its unique ability to stimulate telomerase activity, an enzyme that rebuilds telomeres — protective caps at the ends of chromosomes that naturally shorten with age. By supporting telomere maintenance, Epithalon may help delay cellular senescence, contributing to healthier aging at the molecular level.

Beyond telomere regulation, research suggests Epithalon can enhance antioxidant activity, normalize circadian rhythm regulation, and promote optimal immune and endocrine function. These combined effects make it a compound of interest in the fields of anti-aging, regenerative medicine, and metabolic health.

Research


Over several decades, both preclinical and limited clinical studies have investigated Epithalon’s biological effects. Laboratory research has demonstrated that it can activate telomerase and maintain telomere length in cultured cells, potentially reversing some age-related cellular changes. In animal models, Epithalon administration has been associated with increased lifespan, improved immune system responsiveness, and normalization of hormonal secretion patterns.

Studies also indicate its antioxidant properties, including the ability to reduce lipid peroxidation and oxidative stress markers. These benefits may result from improved mitochondrial efficiency and gene expression modulation linked to stress resistance and longevity. Furthermore, Epithalon has been explored for its potential role in restoring circadian rhythms and regulating melatonin secretion, both of which decline with age. While these results are promising, larger-scale human trials are needed to fully confirm its therapeutic applications.

Product Description

Synonyms: 307297-39-8, Epithalon, Epithalone, UNII-O65P17785G, alanyl-glutamyl-aspartyl-glycine
Molecular Formula: C14H22N4O9
Molar Mass: 390.35 g/mol
CAS Number: 307297-40-1
PubChem: 219042
Total Active Ingredient: 50 mg (1 vial)
Shelf Life: 36 months

Epithalon Structures:

Source PubChem
Product Usage

In vitro research or further manufacturing use only. Not for human or animal use.
Peptide Storage

All information provided by PRG is for educational and informational purposes only.

Best Practices for Storing Peptides

To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.

  • Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
  • Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
  • Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.

Preventing Oxidation & Moisture Damage

Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.

  • Let the vial warm to room temperature before opening to prevent condensation.
  • Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
  • Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.


Storing Peptides in Solution

Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.

  • If storage in solution is unavoidable, use sterile buffers at pH 5–6.
  • Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
  • Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.


Containers for Peptide Storage

Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.

  • Glass vials: offer clarity, durability, and chemical resistance.
  • Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
  • Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.


Regenesis Peptide Storage Quick Tips

  • Keep peptides in a cold, dry, dark environment
  • Avoid repeated freeze–thaw cycles
  • Minimize exposure to air
  • Protect from light
  • Avoid storing in solution long term
  • Aliquot peptides to match experimental needs
Logo for 'Verified Purity' with a shield design, molecular symbol, and text indicating European laboratory standard.

Analytical Transparency

All PRG research materials are analytically tested for purity and identity under EU laboratory standards. Manufacturer Certificates of Analysis (COA) are available upon request. If independent third-party analytical testing confirms results consistent with our published specifications, PRG may reimburse the verified laboratory testing cost upon review.

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