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Vial labeled 'CAGRILINTIDE' with PRG logo on a white background
  • Vial labeled 'CAGRILINTIDE' with PRG logo on a white background
  • Cagrilintide packaging with PRG branding on a white background
  • Green pen on a white background
Cagrilintide 5mg – Research Peptide

Cagrilintide 5mg – Research Peptide

€190,00
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Available Research Formats

Cagrilintide – Research Overview

Cagrilintide is a long-acting amylin analog studied in experimental research for its interaction with appetite-related neuroendocrine signaling and metabolic regulation pathways. Laboratory studies frequently examine its role in satiety signaling, peptide hormone receptor pharmacology, and central energy-balance mechanisms.

Cagrilintide (NNC0174-0833 / AM833) is a synthetic 37-amino-acid peptide derived from human amylin (islet amyloid polypeptide, IAPP). It has been engineered as a long-acting analog designed to interact with amylin receptors (AMYR) and calcitonin receptors (CTR), forming part of a class sometimes referred to as dual amylin receptor/calcitonin receptor agonists (DACRAs).

Molecular Mechanism Research

Amylin and Calcitonin Receptor Interaction

Amylin receptors consist of a calcitonin receptor core complexed with receptor activity-modifying proteins (RAMPs). Cagrilintide has been shown in experimental models to activate these receptor complexes, producing intracellular signaling events associated with satiety-related neuroendocrine pathways.

These receptor systems are highly expressed in several regions involved in metabolic signaling, including:

  • the area postrema

  • the nucleus tractus solitarius (NTS)

  • hypothalamic nuclei associated with energy regulation

Activation of these receptors has been associated in experimental models with modulation of neural circuits involved in satiety signaling and nutrient-responsive feedback pathways.

Central Neuroendocrine Signaling

In preclinical research, cagrilintide has been examined for its influence on central nervous system signaling pathways that regulate energy balance.

Experimental observations suggest receptor activation within brainstem and hypothalamic regions may influence:

  • satiety-related neuronal signaling

  • hypothalamic appetite regulation pathways

  • reward-related food signaling circuits

These neuroendocrine pathways are often studied in research investigating peptide hormone signaling involved in energy homeostasis.

Peripheral Signaling Pathways

Beyond central receptor activity, experimental studies have also reported additional signaling events associated with cagrilintide activity.

These include:

  • cAMP signaling pathways

  • phosphorylation events involving cellular ion transport proteins

  • signaling interactions observed in renal epithelial transport models

Such observations are typically explored in preclinical studies examining peptide hormone signaling and metabolic regulatory pathways.

Structural Characteristics

Cagrilintide is a 37-amino-acid peptide analog derived from the endogenous amylin sequence. Structural modifications have been introduced to improve molecular stability and prolong receptor engagement in experimental models.

These modifications differentiate cagrilintide from earlier amylin analogs, which have also been used in research examining amylin receptor signaling.

Product description:

  • Molecular Formula: C194H312N54O59S2
  • Molecular Weight: 4409 g/mol
  • CAS:  1415456-99-3
  • Total Active Ingredient: 5 mg per vial - ( Vial format: lyophilized powder for enhanced stability.)

Structures:

Cagrilintide structure

Source: PubChem
Product Usage

In vitro research or further manufacturing use only. Not for human or animal use.
Peptide Storage

All information provided by PRG is for educational and informational purposes only.

Best Practices for Storing Peptides

To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.

  • Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
  • Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
  • Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.

Preventing Oxidation & Moisture Damage

Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.

  • Let the vial warm to room temperature before opening to prevent condensation.
  • Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
  • Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.


Storing Peptides in Solution

Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.

  • If storage in solution is unavoidable, use sterile buffers at pH 5–6.
  • Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
  • Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.


Containers for Peptide Storage

Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.

  • Glass vials: offer clarity, durability, and chemical resistance.
  • Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
  • Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.


Regenesis Peptide Storage Quick Tips

  • Keep peptides in a cold, dry, dark environment
  • Avoid repeated freeze–thaw cycles
  • Minimize exposure to air
  • Protect from light
  • Avoid storing in solution long term
  • Aliquot peptides to match experimental needs
Logo for 'Verified Purity' with a shield design, molecular symbol, and text indicating European laboratory standard.

Analytical Transparency

All PRG research materials are analytically tested for purity and identity under EU laboratory standards. Manufacturer Certificates of Analysis (COA) are available upon request. If independent third-party analytical testing confirms results consistent with our published specifications, PRG may reimburse the verified laboratory testing cost upon review.

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