Name: AHK-Cu 100 mg – Hair Follicle Research Peptide (Roller Format)
Brand: PRG
Price: 190.00 EUR
Availability: InStock

Label for AHK-CU with PRG branding and product details on a white background

AHK-Cu 100 mg – Hair Follicle Research Peptide (Roller Format)

€190,00

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AHK-Cu (Copper Tripeptide-3) – Overview and Structure

AHK-Cu (Alanine–Histidine–Lysine Copper), also known as Copper Tripeptide-3, is a synthetic copper-binding tripeptide complex composed of alanine, histidine, and lysine coordinated with a copper (Cu²⁺) ion.

CAS No.: 682809-81-0 (HCl form)

Molecular weight: ~415–451 Da

AHK-Cu is studied as a targeted analog of naturally occurring copper peptides, with particular relevance in research models involving hair follicle biology and dermal papilla cell (DPC) signaling.

The peptide structure enables stable chelation of Cu²⁺ through histidine and peptide backbone interactions, forming a coordinated complex that supports controlled intracellular copper transport and enzyme-related functions.

Molecular Mechanism of Action (Research Context)

AHK-Cu is studied as both a signaling peptide and a bioavailable copper carrier within cellular systems.

In experimental models, it is associated with pathways relevant to dermal papilla cell activity, including:

• cellular proliferation signaling

• apoptosis-related pathway modulation

• growth factor–related signaling pathways

• copper-dependent enzymatic processes

These pathways are explored in relation to hair follicle cycling, particularly mechanisms associated with the anagen (growth) phase.

AHK-Cu is also studied for its interaction with:

• VEGF-related signaling (angiogenesis pathways)

• TGF-β–associated regulatory pathways

• intracellular antioxidant enzyme systems

Copper delivered via the peptide complex is associated with enzyme cofactor activity, including systems linked to oxidative balance and extracellular matrix dynamics.

Hair Follicle Research and Cellular Models

AHK-Cu is frequently examined in in vitro and ex vivo models of hair follicle biology.

Research observations associate the compound with:

• dermal papilla cell signaling activity

• follicular structure dynamics in organ culture models

• cellular environment interactions within the hair follicle niche

These mechanisms are studied in relation to follicle size, structural integrity, and growth-phase signaling pathways.

Skin and Cellular Research Context

In addition to follicle-related pathways, AHK-Cu is also examined in broader skin-related models.

These include:

• fibroblast activity

• collagen-related pathways

• extracellular matrix interactions

• cellular regeneration signaling

This positions AHK-Cu as a compound of interest in both hair-focused and dermal research environments.

Comparative Research Overview

Property	AHK-Cu (Copper Tripeptide-3)	GHK-Cu (Copper Tripeptide-1)
Sequence	Ala-His-Lys-Cu²⁺	Gly-His-Lys-Cu²⁺
CAS Number	682809-81-0	49557-75-7
Molecular Weight	~415–451 Da	~340–404 Da
Origin	Synthetic analog	Naturally occurring peptide
Primary Research Focus	Hair follicle / DPC models	Broad skin-related pathways
Mechanistic Focus	DPC signaling, pathway modulation	Fibroblast signaling, ECM pathways
Hair Research Relevance	High	Moderate
Skin Research Relevance	Secondary	Primary
Research Context	In vitro / ex vivo follicle studies	Extensive skin-related models

Research Applications and Context

AHK-Cu is studied in experimental systems focusing on:

• hair follicle biology

• dermal papilla cell signaling

• copper-dependent enzyme activity

• angiogenesis-related pathways

• extracellular matrix regulation

It is frequently included in research exploring targeted peptide delivery systems and localized cellular signaling environments.

Summary

AHK-Cu (Copper Tripeptide-3) is a synthetic copper-binding peptide studied in relation to hair follicle biology, dermal papilla cell signaling, and copper-dependent cellular pathways.

Its mechanisms are associated with:

• cellular signaling and proliferation pathways

• growth factor–related systems

• antioxidant and enzymatic processes

• extracellular matrix interactions

These properties make it a relevant compound in research focused on localized cellular environments and peptide-mediated signaling systems.

All information provided reflects research-based observations in experimental models and is intended for scientific and educational purposes.

Delivery System and Format (Research Context)

This product is presented as a roller-based peptide delivery system integrating AHK-Cu within a manual applicator format.

The device features a 64-pin roller head with ultra-fine 0.5 mm gold-tipped titanium needles and an integrated reservoir system designed to hold the peptide solution within the applicator structure.

In experimental and cosmetic research settings, microneedle-based systems are studied for their ability to create controlled micro-scale surface channels, allowing localized interaction between peptide compounds and the surrounding skin environment.

The roller format is associated with uniform distribution across the application surface and consistent contact between the peptide solution and targeted areas in controlled models.

The device operates mechanically without the need for external power sources and is constructed using materials selected for stability and compatibility in topical research environments.

Gold-tipped titanium components are commonly used in such systems due to their structural properties and surface characteristics in repeated-contact applications.

This format is examined in research exploring localized peptide delivery, surface interaction dynamics, and controlled distribution systems.

This section describes the delivery format and presentation of the product within experimental and cosmetic research contexts.

In vitro research or further manufacturing use only. Not for human or animal use.

All information provided by PRG is for educational and informational purposes only.

Best Practices for Storing Peptides

To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.

Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.

Preventing Oxidation & Moisture Damage

Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.

Let the vial warm to room temperature before opening to prevent condensation.
Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.

Storing Peptides in Solution

Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.

If storage in solution is unavoidable, use sterile buffers at pH 5–6.
Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.

Containers for Peptide Storage

Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.

Glass vials: offer clarity, durability, and chemical resistance.
Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.

Regenesis Peptide Storage Quick Tips

Keep peptides in a cold, dry, dark environment
Avoid repeated freeze–thaw cycles
Minimize exposure to air
Protect from light
Avoid storing in solution long term
Aliquot peptides to match experimental needs

Analytical Transparency

All PRG research materials are analytically tested for purity and identity under EU laboratory standards. Manufacturer Certificates of Analysis (COA) are available upon request. If independent third-party analytical testing confirms results consistent with our published specifications, PRG may reimburse the verified laboratory testing cost upon review.

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AHK-Cu 100 mg – Hair Follicle Research Peptide (Roller Format)

AHK-Cu (Copper Tripeptide-3) – Overview and Structure

Molecular Mechanism of Action (Research Context)