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Further research background:
5-Amino-1MQ – High Purity Research Molecule (50mg)
€180,00
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Overview:
5-Amino-1MQ is a small-molecule compound that inhibits the enzyme nicotinamide N-methyltransferase (NNMT), a key regulator of cellular energy balance and metabolic pathways, with notable activity in adipose tissue. Inhibition of NNMT has been associated with increased availability of nicotinamide adenine dinucleotide (NAD⁺), an essential cofactor in cellular metabolism, which may influence mitochondrial activity and support NAD⁺-dependent signaling processes, including sirtuin-1 (SIRT1) activation.
SIRT1, often studied in the context of metabolic regulation and cellular stress response, has been linked in research literature to pathways relevant to metabolic health, lipid metabolism, and age-associated cellular function. In preclinical research models, modulation of NNMT activity has been examined for its potential effects on adipocyte metabolism and energy utilization under controlled experimental conditions. These findings suggest that altered NNMT signaling may influence fat cell biology and metabolic efficiency without directly affecting caloric intake.
Product Description
Synonyms: 5-amino-1-methylquinolinium, SCHEMBL6403148, CHEMBL4116828, ZINC552049, STL196667
Molar Mass: 159.21 g/mol
CAS Number: 42464-96-0
PubChem ID: 950107
Total Active Ingredient: 6000 mg per container (50 mg per capsule)
Shelf Life: 36 months
Further research background:
→ What Is 5-Amino-1MQ? – Understanding NNMT inhibition in research models
5-Amino-1MQ Structures
Sources PubChem
Research Context
Nicotinamide N-methyltransferase (NNMT) has been widely studied as a regulator of cellular metabolism and energy balance, with particular relevance in adipose tissue and metabolic signaling pathways. NNMT activity influences the flux of nicotinamide and S-adenosylmethionine (SAM) within the NAD⁺ salvage pathway and methionine cycle, positioning it as an important enzyme in metabolic research.
In laboratory investigations, small-molecule NNMT inhibitors have been evaluated for membrane permeability, selectivity, and biochemical activity. In vitro studies have demonstrated that NNMT inhibition can reduce intracellular levels of 1-methylnicotinamide (1-MNA), while increasing NAD⁺ and SAM availability and modulating lipogenic signaling in cultured adipocytes under controlled experimental conditions.
Preclinical research models have further explored the metabolic effects of NNMT modulation, highlighting its role in adipocyte function, lipid metabolism, and systemic energy regulation. These findings have established NNMT inhibition as an active area of investigation in metabolic and cellular energy research, particularly in studies examining NAD⁺-dependent pathways and metabolic homeostasis.
Related research focus:
→ NAD⁺ – Research-Grade Compound for cellular energy metabolism
Source: ScienceDirect
Product Usage
This item is supplied for research purposes only.
Peptide Storage
All information provided by PRG is for educational and informational purposes only.
Best Practices for Storing Peptides
To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.
- Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
- Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
- Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.
Preventing Oxidation & Moisture Damage
Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.
- Let the vial warm to room temperature before opening to prevent condensation.
- Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
- Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.
Storing Peptides in Solution
Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.
- If storage in solution is unavoidable, use sterile buffers at pH 5–6.
- Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
- Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.
Containers for Peptide Storage
Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.
- Glass vials: offer clarity, durability, and chemical resistance.
- Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
- Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.
Regenesis Peptide Storage Quick Tips
- Keep peptides in a cold, dry, dark environment
- Avoid repeated freeze–thaw cycles
- Minimize exposure to air
- Protect from light
- Avoid storing in solution long term
- Aliquot peptides to match experimental needs