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1-MNA (1-Methylnicotinamide) 60mg – Research Compound
  • 1-MNA (1-Methylnicotinamide) 60mg – Research Compound
  • 1-MNA (1-Methylnicotinamide) 60mg – Research Compound
1-MNA (1-Methylnicotinamide) 60mg – Research Compound

1-MNA (1-Methylnicotinamide) 60mg – Research Compound

€90,00
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1-MNA is a naturally occurring molecule studied in research models related to NAD⁺ metabolism, cellular energy balance, and vascular signaling. It is frequently referenced in experimental studies exploring metabolic and longevity-associated pathways.

1-Methylnicotinamide chloride powder (1-MNA or MNA), also known as NMN-Cl, 1-MNA chloride, 3-carbamoyl-1-methyl-pyridinium chloride, or MNC, is a naturally occurring nicotinamide metabolite produced from nicotinamide through the action of N-methyltransferase (NNMT), which methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor. Long considered an inert excretion product in urine, recent peer-reviewed research establishes 1-MNA as a signaling molecule with anti-inflammatory, antioxidant, anti-thrombotic, anti-fibrotic, and metabolic regulatory effects. It is produced in multiple tissues (liver, skeletal muscle, kidney) and shows promise as a supplement for improving exercise tolerance, reducing fatigue, and protecting cardiometabolic health.

Biosynthesis and Role as Myokine in Energy Metabolism NNMT is the most consistently upregulated gene in human skeletal muscle after energy-deficit exercise (high-volume, low-intensity training + caloric restriction). Isolated human myotubes secrete 1-MNA, a novel myokine that directly stimulates lipolysis in adipose tissue to mobilize energy stores, with no effect on glucagon or insulin. This coordinates systemic energy utilization during low muscle energy availability and may sense cellular redox shifts (Ström et al., Sci Rep 2018; doi:10.1038/s41598-018-21099-1).

In hepatocytes, NNMT overexpression or 1-MNA treatment stabilizes SIRT1 protein (reducing ubiquitination/proteasomal degradation), inversely correlating with FoxO1 acetylation. SIRT1 activity modulates gluconeogenesis and suppresses cholesterol synthesis/lipogenesis, supporting metabolic homeostasis (Roberti et al., Mol Metab 2021; doi:10.1016/j.molmet.2021.101165; Hong et al., J Biol Chem 2015).

Anti-Inflammatory, Antioxidant, and Tissue-Protective Effects 1-MNA inhibits NF-κB activation (preventing p65 nuclear translocation, restoring IκB-α) and upregulates Nrf2 plus downstream antioxidants (HO-1, NQO1).

- It reduces ROS, inflammation (TNF-α, IL-6, IL-1β ↓ 34–56%), apoptosis (cleaved caspase-3, BAX/BCL2, TUNEL ↓), hypertrophy, and fibrosis (TGF-β, COL-1, CTGF ↓; collagen volume ↓) in cardiomyocytes and heart tissue.

- It also lowers plasma triglycerides (↓14%) and LDL (↓35%) (Song et al., Front Cardiovasc Med 2021; doi:10.3389/fcvm.2021.721814).

Additional benefits:

- Ameliorates lipid toxicity-induced oxidative stress/cell death in renal proximal tubular cells (in vitro/in vivo).
- Inhibits NLRP3 inflammasome in human macrophages via ROS reduction (no effect on IL-6 from endotoxin alone).
- Prevents endothelial dysfunction and improves exercise capacity in diabetic/hypertriglyceridemic models; exerts COX-2/prostacyclin-mediated anti-thrombotic activity.
- Anti-fibrotic effects are partly mediated by SIRT1 activation, which inhibits TGF-β signaling.
Product Usage

In vitro research or further manufacturing use only. Not for human or animal use.
Peptide Storage

All information provided by PRG is for educational and informational purposes only.

Best Practices for Storing Peptides

To maintain the reliability of laboratory results, correct peptide storage is essential. Proper storage conditions help preserve peptide stability for years while protecting against contamination, oxidation, and breakdown. Although certain peptides are more sensitive than others, following these best practices will greatly extend their shelf life and structural integrity.

  • Short-Term Storage (days to months): Keep peptides cool and protected from light. Temperatures below 4 °C (39 °F) are generally suitable. Lyophilized peptides often remain stable at room temperature for several weeks, but refrigeration is still preferred if use is not immediate.
  • Long-Term Storage (months to years): Store peptides at –80 °C (–112 °F) for maximum stability. Avoid frost-free freezers, as defrost cycles can cause damaging temperature fluctuations.
  • Minimize Freeze–Thaw Cycles: Repeated freezing and thawing accelerates degradation. Instead, divide peptides into aliquots before freezing.

Preventing Oxidation & Moisture Damage

Peptides can be compromised by exposure to moisture and air—especially immediately after removal from a freezer.

  • Let the vial warm to room temperature before opening to prevent condensation.
  • Keep containers sealed as much as possible, and if possible, reseal under a dry, inert gas such as nitrogen or argon.
  • Amino acids like cysteine (C), methionine (M), and tryptophan (W) are particularly sensitive to oxidation.


Storing Peptides in Solution

Peptides in solution have a much shorter lifespan compared to lyophilized form and are prone to bacterial degradation.

  • If storage in solution is unavoidable, use sterile buffers at pH 5–6.
  • Prepare single-use aliquots to avoid repeated freeze–thaw cycles.
  • Most peptide solutions are stable for up to 30 days at 4 °C (39 °F), but sensitive sequences should remain frozen when not in use.


Containers for Peptide Storage

Select containers that are clean, intact, chemically resistant, and appropriately sized for the sample.

  • Glass vials: offer clarity, durability, and chemical resistance.
  • Plastic vials: polystyrene (clear but less resistant) or polypropylene (translucent but chemically resistant).
  • Peptides shipped in plastic vials may be transferred to glass for long-term storage if desired.


Regenesis Peptide Storage Quick Tips

  • Keep peptides in a cold, dry, dark environment
  • Avoid repeated freeze–thaw cycles
  • Minimize exposure to air
  • Protect from light
  • Avoid storing in solution long term
  • Aliquot peptides to match experimental needs
Logo for 'Verified Purity' with a shield design, molecular symbol, and text indicating European laboratory standard.

Analytical Transparency

All PRG research materials are analytically tested for purity and identity under EU laboratory standards. Manufacturer Certificates of Analysis (COA) are available upon request. If independent third-party analytical testing confirms results consistent with our published specifications, PRG may reimburse the verified laboratory testing cost upon review.

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