{"product_id":"tirzepatide-20mg","title":"Tirzepatide 20mg – Research Peptide","description":"\u003cp\u003e\u003cstrong\u003eStructure, Molecular Mechanism of Action, Receptor Interactions:\u003c\/strong\u003e Tirzepatide is a first-in-class, unimolecular, long-acting dual GIP\/GLP-1 receptor agonist (39-amino acid syntheticlinear peptide.\u003c\/p\u003e\n\u003cp\u003eTirzepatide is a dual incretin receptor agonist studied for its effects on metabolic signaling and energy regulation pathways. In research models, it is examined for its interaction with glucose balance, appetite-related signaling, and hormonal coordination.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eMolecular Mechanism of Action :\u003c\/strong\u003e Tirzepatide is a dual agonist of the glucose-dependent\u003cbr\u003einsulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R),\u003cbr\u003eboth class B GPCRs. Tirzepatide exhibits imbalanced agonism (preferential GIPR engagement) and biased signaling at GLP-1R, driving its superior glycemic\/weight effects vs. GLP-1R mono-agonists.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eGIPR: Unbiased; full mimicry of GIP (Gs → ↑cAMP → PKA; β-arrestin2;\u003cbr\u003einternalization).\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eGLP-1R: Biased partial agonist favoring Gs\/cAMP\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDownstream Molecular\/Physiologic Effects (Glucose-Dependent):\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePancreatic β-cells (both receptors): Gs–cAMP–PKA → voltage-gated Ca²⁺\u003cbr\u003einflux\/exocytosis → insulin secretion; improved β-cell function\/sensitivity.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eα-cells (GLP-1R dominant): Glucagon suppression.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eGI (GLP-1R): Delayed gastric emptying; satiety\/appetite reduction (central\u003cbr\u003ehypothalamic arcuate\/paraventricular neurons).\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eAdipose\/liver\/muscle (GIPR + GLP-1R): Enhanced insulin sensitivity, lipid buffering\u003cbr\u003e(↑adiponectin), reduced ectopic fat, improved metabolic flexibility.\u003cbr\u003e\u003cbr\u003e\n\u003c\/li\u003e\n\u003cli\u003eCNS: Reduced food intake\/energy intake; sustained signaling from bias may enhance weight loss durability. Net: Superior HbA1c reduction (1.6–2.4%), weight loss (15–21% at 72 wk), cardiometabolic benefits (lipids, BP) vs. GLP-1 mono-agonists.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eWant to understand the receptor signaling behind this compound?\u003c\/h3\u003e\n\u003cp\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/what-is-tirzepatide\"\u003eWhat is Tirzepatide? Dual GLP-1\/GIP Peptide Explained\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eExplore how dual-receptor incretin signaling compares with next-generation triple agonists.\u003c\/h3\u003e\n\u003cp\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/retatrutide-tirzepatide\"\u003eRetatrutide vs Tirzepatide: Mechanism Comparison\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e\u003cstrong\u003eTirzepatide is commonly examined in research involving incretin signaling and metabolic regulation. \u003c\/strong\u003e\u003cstrong\u003eFor a broader perspective on how injectable peptides compare with oral compounds:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/oral-vs-injectable-metabolic-peptides-research\"\u003eOral vs Injectable Compounds (Orforglipron, Tirzepatide, Retatrutide)\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e \u003c\/p\u003e\n\u003ch3\u003eTo explore how incretin-based signaling pathways interact with muscle metabolism and adaptive physiology in research models, see:\u003c\/h3\u003e\n\u003cp\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/muscle-preservation-during-glp-1-gip-therapy\"\u003eMuscle Preservation During GLP-1\/GIP Therapy\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3\u003eProduct description:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cstrong\u003eMolecular Formula: \u003c\/strong\u003e\u003cspan\u003eC\u003csub\u003e225\u003c\/sub\u003eH\u003csub\u003e348\u003c\/sub\u003eN\u003csub\u003e48\u003c\/sub\u003eO\u003csub\u003e68\u003c\/sub\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cdiv class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4813\u003cspan\u003e \u003c\/span\u003eg\/m   \u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cspan\u003e\u003cstrong\u003eCAS:\u003c\/strong\u003e \u003c\/span\u003e2023788-19-2\u003c\/li\u003e\n\u003cli class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cdiv class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cstrong data-end=\"875\" data-start=\"847\"\u003eTotal Active Ingredient:\u003c\/strong\u003e 20 mg per vial - ( Vial format: lyophilized powder for enhanced stability.)\u003cbr\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eStructures:\u003c\/h3\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cimg style=\"margin-bottom: 16px; float: none;\" alt=\"Tirzepatide structure\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/tirzepatide.png?v=1772702974\"\u003e\u003c\/div\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/156588324\"\u003e\u003cstrong\u003eSource: Pubchem\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"PRG","offers":[{"title":"Vial","offer_id":52641769521418,"sku":null,"price":180.0,"currency_code":"EUR","in_stock":true},{"title":"Pre-filled Pen ( 1 )","offer_id":52641769554186,"sku":null,"price":205.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Tirzepatide_2.png?v=1772286816","url":"https:\/\/www.peptideregenesis.com\/products\/tirzepatide-20mg","provider":"PRG","version":"1.0","type":"link"}