{"product_id":"semax-10mg","title":"Semax 10mg – Neuroactive Research Peptide","description":"\u003ch3 data-end=\"762\" data-start=\"735\" data-section-id=\"1lpkwfh\"\u003e\u003cstrong\u003eSemax – Research Overview\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-end=\"1084\" data-start=\"764\"\u003eSemax is a synthetic neuropeptide studied in experimental research models examining neurochemical signaling, neurotrophic pathway regulation, and central nervous system adaptive responses. It is frequently referenced in studies investigating BDNF expression, synaptic plasticity mechanisms, and neuroendocrine signaling.\u003c\/p\u003e\n\u003cp data-end=\"1084\" data-start=\"764\"\u003eThe peptide was originally developed as a modified analog of the \u003cstrong data-end=\"1355\" data-start=\"1332\"\u003eACTH(4-10) fragment\u003c\/strong\u003e derived from adrenocorticotropic hormone. Structural extension with the stabilizing tripeptide \u003cstrong data-end=\"1472\" data-start=\"1451\"\u003ePro-Gly-Pro (PGP)\u003c\/strong\u003e increases resistance to enzymatic degradation and improves stability in experimental delivery models.\u003c\/p\u003e\n\u003ch3 data-end=\"1611\" data-start=\"1581\" data-section-id=\"5fqgg6\"\u003eMolecular Mechanism Research\u003c\/h3\u003e\n\u003ch3 data-end=\"1658\" data-start=\"1613\" data-section-id=\"1uxzxoy\"\u003eNeurotrophic Signaling and BDNF Regulation\u003c\/h3\u003e\n\u003cp data-end=\"1789\" data-start=\"1660\"\u003eOne of the most widely studied mechanisms of Semax involves modulation of \u003cstrong data-end=\"1778\" data-start=\"1734\"\u003ebrain-derived neurotrophic factor (BDNF)\u003c\/strong\u003e signaling.\u003c\/p\u003e\n\u003cp data-end=\"1851\" data-start=\"1791\"\u003eExperimental studies have reported that Semax can influence:\u003c\/p\u003e\n\u003cul data-end=\"1983\" data-start=\"1853\"\u003e\n\u003cli data-end=\"1880\" data-start=\"1853\" data-section-id=\"1x8ztfz\"\u003e\n\u003cp data-end=\"1880\" data-start=\"1855\"\u003eBDNF protein expression\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1946\" data-start=\"1881\" data-section-id=\"1nlkjgk\"\u003e\n\u003cp data-end=\"1946\" data-start=\"1883\"\u003eBDNF mRNA transcription (including exon-specific transcripts)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"1983\" data-start=\"1947\" data-section-id=\"1buidk5\"\u003e\n\u003cp data-end=\"1983\" data-start=\"1949\"\u003eTrkB receptor signaling activation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"2054\" data-start=\"1985\"\u003eThese effects have been observed in several brain regions, including:\u003c\/p\u003e\n\u003cul data-end=\"2109\" data-start=\"2056\"\u003e\n\u003cli data-end=\"2071\" data-start=\"2056\" data-section-id=\"5ynrz3\"\u003e\n\u003cp data-end=\"2071\" data-start=\"2058\"\u003ehippocampus\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2091\" data-start=\"2072\" data-section-id=\"ujdhdp\"\u003e\n\u003cp data-end=\"2091\" data-start=\"2074\"\u003ebasal forebrain\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"2109\" data-start=\"2092\" data-section-id=\"1khwccz\"\u003e\n\u003cp data-end=\"2109\" data-start=\"2094\"\u003ecerebral cortex\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"2245\" data-start=\"2111\"\u003eActivation of \u003cstrong data-end=\"2143\" data-start=\"2125\"\u003eTrkB receptors\u003c\/strong\u003e can initiate multiple downstream signaling cascades associated with neuronal plasticity and survival.\u003c\/p\u003e\n\u003ch3 data-end=\"2296\" data-start=\"2247\" data-section-id=\"prw0u9\"\u003eKey downstream pathways investigated include:\u003c\/h3\u003e\n\u003cp data-end=\"2316\" data-start=\"2298\"\u003e\u003cstrong data-end=\"2316\" data-start=\"2298\"\u003ePLCγ signaling\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-end=\"2401\" data-start=\"2318\"\u003ePLCγ → IP3\/DAG → Ca²⁺ signaling → CaMK activation → CREB transcriptional regulation\u003c\/p\u003e\n\u003cp data-end=\"2425\" data-start=\"2403\"\u003e\u003cstrong data-end=\"2425\" data-start=\"2403\"\u003eMAPK \/ ERK pathway\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-end=\"2538\" data-start=\"2427\"\u003eRas → Raf → MEK → ERK signaling, frequently associated with neuronal growth and synaptic plasticity mechanisms.\u003c\/p\u003e\n\u003cp data-end=\"2564\" data-start=\"2540\"\u003e\u003cstrong data-end=\"2564\" data-start=\"2540\"\u003ePI3K \/ Akt signaling\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-end=\"2699\" data-start=\"2566\"\u003ePI3K\/Akt pathways are commonly investigated in research examining neuronal survival signaling and anti-apoptotic cellular mechanisms.\u003c\/p\u003e\n\u003cp data-end=\"2827\" data-start=\"2701\"\u003eThese pathways are widely studied in experimental models exploring synaptic plasticity, neurogenesis, and neuronal adaptation.\u003c\/p\u003e\n\u003ch3 data-end=\"2870\" data-start=\"2834\" data-section-id=\"tvgtqv\"\u003eMonoamine Neurotransmitter Systems\u003c\/h3\u003e\n\u003cp data-end=\"2992\" data-start=\"2872\"\u003eSemax has also been examined in experimental research investigating \u003cstrong data-end=\"2991\" data-start=\"2940\"\u003edopaminergic and serotonergic neurotransmission\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-end=\"3039\" data-start=\"2994\"\u003ePreclinical studies have reported changes in:\u003c\/p\u003e\n\u003cul data-end=\"3209\" data-start=\"3041\"\u003e\n\u003cli data-end=\"3091\" data-start=\"3041\" data-section-id=\"1olrog\"\u003e\n\u003cp data-end=\"3091\" data-start=\"3043\"\u003edopamine release dynamics in striatal pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3139\" data-start=\"3092\" data-section-id=\"bxsajx\"\u003e\n\u003cp data-end=\"3139\" data-start=\"3094\"\u003eserotonin metabolism markers such as 5-HIAA\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"3209\" data-start=\"3140\" data-section-id=\"1wtezax\"\u003e\n\u003cp data-end=\"3209\" data-start=\"3142\"\u003emonoamine signaling associated with motivation and reward circuitry\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"3357\" data-start=\"3211\"\u003eThese neurotransmitter systems are frequently studied in research exploring attention, cognitive signaling pathways, and neurochemical regulation.\u003c\/p\u003e\n\u003ch3 data-end=\"3397\" data-start=\"3364\" data-section-id=\"1wg5iy8\"\u003eMelanocortin System Interaction\u003c\/h3\u003e\n\u003cp data-end=\"3525\" data-start=\"3399\"\u003eBecause Semax is derived from an ACTH fragment, it has also been examined for its interaction with \u003cstrong data-end=\"3524\" data-start=\"3498\"\u003emelanocortin receptors\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp data-end=\"3781\" data-start=\"3527\"\u003eExperimental data suggest Semax may interact with \u003cstrong data-end=\"3602\" data-start=\"3577\"\u003eMC4 and MC5 receptors\u003c\/strong\u003e, influencing signaling pathways involved in stress physiology and inflammatory regulation. Many observed effects appear independent of classical melanocortin receptor activation.\u003c\/p\u003e\n\u003ch3 data-end=\"3833\" data-start=\"3788\" data-section-id=\"e76rl2\"\u003eEnkephalinase and Opioid System Interaction\u003c\/h3\u003e\n\u003cp data-end=\"3960\" data-start=\"3835\"\u003eSome experimental studies have reported that Semax may inhibit enzymes involved in the degradation of endogenous enkephalins.\u003c\/p\u003e\n\u003cp data-end=\"4106\" data-start=\"3962\"\u003eBy influencing these enzymatic pathways, Semax has been investigated in models studying endogenous opioid signaling and neuropeptide regulation.\u003c\/p\u003e\n\u003ch3 data-end=\"4159\" data-start=\"4113\" data-section-id=\"16racw5\"\u003eGene Expression and Cellular Response Models\u003c\/h3\u003e\n\u003cp data-end=\"4298\" data-start=\"4161\"\u003eGenome-wide transcription studies in experimental models have reported that Semax may influence gene expression patterns associated with:\u003c\/p\u003e\n\u003cul data-end=\"4429\" data-start=\"4300\"\u003e\n\u003cli data-end=\"4326\" data-start=\"4300\" data-section-id=\"4k306m\"\u003e\n\u003cp data-end=\"4326\" data-start=\"4302\"\u003eneurotrophic signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4357\" data-start=\"4327\" data-section-id=\"134grtj\"\u003e\n\u003cp data-end=\"4357\" data-start=\"4329\"\u003evascular response pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4395\" data-start=\"4358\" data-section-id=\"zolgl6\"\u003e\n\u003cp data-end=\"4395\" data-start=\"4360\"\u003eimmune-related gene transcription\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"4429\" data-start=\"4396\" data-section-id=\"1rshgzp\"\u003e\n\u003cp data-end=\"4429\" data-start=\"4398\"\u003eneurotransmission-related genes\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-end=\"4592\" data-start=\"4431\"\u003eAdditional experimental observations include modulation of oxidative stress markers, nitric-oxide signaling pathways, and calcium homeostasis in neuronal models.\u003c\/p\u003e\n\u003ch3 data-end=\"4652\" data-start=\"4599\" data-section-id=\"kh9l9u\"\u003eMetal Ion Interaction and Oxidative Stress Research\u003c\/h3\u003e\n\u003cp data-end=\"4848\" data-start=\"4654\"\u003eSome experimental studies have also reported that Semax can interact with \u003cstrong data-end=\"4755\" data-start=\"4728\"\u003emetal ions such as Cu²⁺\u003c\/strong\u003e, forming stable complexes that influence peptide stability and cellular oxidative signaling.\u003c\/p\u003e\n\u003cp data-end=\"4969\" data-start=\"4850\"\u003eThese mechanisms have been investigated in research examining oxidative stress pathways and protein aggregation models.\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eRelated Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eSemax is frequently examined in experimental neuroscience models exploring neurotrophic signaling, neurotransmitter regulation, and adaptive neuronal plasticity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFor a deeper explanation of the peptide’s structure and signaling mechanisms, see our research overview:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e→ \u003c\/span\u003e\u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/what-is-semax\"\u003e\u003cspan\u003eWhat Is Semax? Mechanism and Neurotrophic Signaling\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eResearchers also often compare Semax with related neuroactive peptides studied for central nervous system signaling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e→ \u003c\/span\u003e\u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/semax-vs-selank-vs-dihexa\"\u003e\u003cspan\u003eSelank vs Semax vs Dihexa – Comparative Research Overview\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003ch3 data-end=\"4997\" data-start=\"4976\" data-section-id=\"15qw8x\"\u003e\n\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/h3\u003e\n\u003ch3 data-end=\"4997\" data-start=\"4976\" data-section-id=\"15qw8x\"\u003e\u003cstrong\u003eProduct Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-end=\"5193\" data-start=\"4999\"\u003e\u003cstrong data-end=\"5012\" data-start=\"4999\"\u003eSynonyms:\u003c\/strong\u003e Semax peptide, MEHFPGP peptide\u003cbr data-end=\"5046\" data-start=\"5043\"\u003e\u003cstrong data-end=\"5059\" data-start=\"5046\"\u003eSequence:\u003c\/strong\u003e Met-Glu-His-Phe-Pro-Gly-Pro\u003cbr data-end=\"5090\" data-start=\"5087\"\u003e\u003cstrong data-end=\"5109\" data-start=\"5090\"\u003eCAS:\u003c\/strong\u003e 80714-61-0\u003cbr data-end=\"5126\" data-start=\"5123\"\u003e\u003cstrong data-end=\"5148\" data-start=\"5126\"\u003eMolecular Formula:\u003c\/strong\u003e C₃₇H₅₁N₉O₁₀S\u003cbr data-end=\"5164\" data-start=\"5161\"\u003e\u003cstrong data-end=\"5185\" data-start=\"5164\"\u003eMolecular Weight:\u003c\/strong\u003e ~813.9 g\/mol\u003c\/p\u003e\n\u003ch3 data-end=\"5252\" data-start=\"5200\" data-section-id=\"orlbwh\"\u003eResearch Areas Referenced in Scientific Literature\u003c\/h3\u003e\n\u003cp data-end=\"5324\" data-start=\"5254\"\u003eSemax is frequently referenced in experimental research investigating:\u003c\/p\u003e\n\u003cul data-end=\"5536\" data-start=\"5326\"\u003e\n\u003cli data-end=\"5361\" data-start=\"5326\" data-section-id=\"sec8a3\"\u003e\n\u003cp data-end=\"5361\" data-start=\"5328\"\u003eBDNF and neurotrophic signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5408\" data-start=\"5362\" data-section-id=\"b1t26a\"\u003e\n\u003cp data-end=\"5408\" data-start=\"5364\"\u003esynaptic plasticity and neuronal signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5450\" data-start=\"5409\" data-section-id=\"s67sr\"\u003e\n\u003cp data-end=\"5450\" data-start=\"5411\"\u003emonoamine neurotransmitter regulation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5485\" data-start=\"5451\" data-section-id=\"1t90rwd\"\u003e\n\u003cp data-end=\"5485\" data-start=\"5453\"\u003emelanocortin pathway signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-end=\"5536\" data-start=\"5486\" data-section-id=\"mb3sip\"\u003e\n\u003cp data-end=\"5536\" data-start=\"5488\"\u003eoxidative stress and neuronal metabolic pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 class=\"flex items-end font-medium leading-tight break-words text-2xl lg:text-3xl\"\u003e\u003cspan class=\"flex-1\"\u003eStructures:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\u003cimg style=\"margin-bottom: 16px; float: none;\" alt=\"semax Structures\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/semax.png?v=1772792942\"\u003e\u003c\/div\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/9811102\"\u003eSource: PubChem\u003c\/a\u003e\u003c\/div\u003e","brand":"PRG","offers":[{"title":"Vial","offer_id":52641701986570,"sku":null,"price":120.0,"currency_code":"EUR","in_stock":true},{"title":"Pre-filled Pen ( 1 )","offer_id":52641702019338,"sku":null,"price":145.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Semax10mg_2.png?v=1772290152","url":"https:\/\/www.peptideregenesis.com\/products\/semax-10mg","provider":"PRG","version":"1.0","type":"link"}