{"product_id":"mazdutide-research-peptide","title":"Mazdutide 10 mg – Multi-Receptor Metabolic Research Peptide","description":"\u003ch3 data-section-id=\"1ga2phu\" data-start=\"0\" data-end=\"105\"\u003eMazdutide (IBI362 \/ LY3305677, CAS 2259884-03-0): Molecular Mechanism and Metabolic Research Overview\u003c\/h3\u003e\n\u003cp data-start=\"107\" data-end=\"452\"\u003eMazdutide is a synthetic dual peptide agonist studied for its interaction with glucagon-like peptide-1 receptors (GLP-1R) and glucagon receptors (GCGR). Originally developed as LY3305677 and later advanced by Innovent Biologics, it is structurally based on oxyntomodulin (OXM), an endogenous peptide associated with metabolic signaling pathways.\u003c\/p\u003e\n\u003cp data-start=\"454\" data-end=\"805\"\u003eMazdutide is engineered as a long-acting peptide analog designed to support sustained receptor interaction in experimental and clinical research settings. Its structure combines GLP-1R and GCGR agonism in a balanced signaling profile, making it relevant for studies involving energy regulation, endocrine signaling, and metabolic pathway coordination.\u003c\/p\u003e\n\u003ch3 data-section-id=\"1y7bgok\" data-start=\"812\" data-end=\"853\"\u003eMolecular Design and Receptor Binding\u003c\/h3\u003e\n\u003cp data-start=\"855\" data-end=\"1009\"\u003eMazdutide is a linear peptide built on the mammalian oxyntomodulin backbone, which contains the glucagon sequence with an additional C-terminal extension.\u003c\/p\u003e\n\u003cp data-start=\"1011\" data-end=\"1194\"\u003eTargeted amino acid modifications and lipidation strategies enhance resistance to enzymatic degradation, improve albumin binding, and prolong circulation time in experimental systems.\u003c\/p\u003e\n\u003cp data-start=\"1196\" data-end=\"1440\"\u003eBoth GLP-1R and GCGR belong to the class B G-protein-coupled receptor (GPCR) family. Ligand binding induces conformational changes in extracellular and transmembrane receptor domains, promoting activation of intracellular Gs signaling pathways.\u003c\/p\u003e\n\u003cp data-start=\"1442\" data-end=\"1563\"\u003eMazdutide stabilizes active receptor conformations across both receptor systems, enabling coordinated signaling activity.\u003c\/p\u003e\n\u003ch3 data-section-id=\"w8vdgj\" data-start=\"1570\" data-end=\"1642\"\u003eDownstream Signaling: Cyclic Adenosine Monophosphate (cAMP) Pathways\u003c\/h3\u003e\n\u003cp data-start=\"1644\" data-end=\"1835\"\u003eThe primary signaling mechanism for both receptors involves activation of adenylyl cyclase through Gs proteins, leading to elevated intracellular cyclic adenosine monophosphate (cAMP) levels.\u003c\/p\u003e\n\u003cp data-start=\"1837\" data-end=\"1941\"\u003eIncreased cAMP activates protein kinase A (PKA), which modulates multiple downstream cellular processes.\u003c\/p\u003e\n\u003ch4 data-start=\"1943\" data-end=\"1963\"\u003eGLP-1R Pathways\u003c\/h4\u003e\n\u003cp data-start=\"1965\" data-end=\"2016\"\u003eGLP-1 receptor signaling is studied in relation to:\u003c\/p\u003e\n\u003cp data-start=\"2018\" data-end=\"2135\"\u003e• pancreatic endocrine signaling\u003cbr data-start=\"2050\" data-end=\"2053\"\u003e• gastrointestinal regulatory pathways\u003cbr data-start=\"2091\" data-end=\"2094\"\u003e• hypothalamic nutrient-sensing systems\u003c\/p\u003e\n\u003ch4 data-start=\"2142\" data-end=\"2160\"\u003eGCGR Pathways\u003c\/h4\u003e\n\u003cp data-start=\"2162\" data-end=\"2209\"\u003eGlucagon receptor signaling is associated with:\u003c\/p\u003e\n\u003cp data-start=\"2211\" data-end=\"2353\"\u003e• hepatic metabolic regulation\u003cbr data-start=\"2241\" data-end=\"2244\"\u003e• lipid metabolism pathways\u003cbr data-start=\"2271\" data-end=\"2274\"\u003e• mitochondrial fatty acid oxidation\u003cbr data-start=\"2310\" data-end=\"2313\"\u003e• energy expenditure signaling systems\u003c\/p\u003e\n\u003ch3 data-section-id=\"hocnt\" data-start=\"2360\" data-end=\"2394\"\u003eIntegrated Metabolic Signaling\u003c\/h3\u003e\n\u003cp data-start=\"2396\" data-end=\"2511\"\u003eMazdutide is studied for its ability to engage both appetite-related and energy-regulation pathways simultaneously.\u003c\/p\u003e\n\u003cp data-start=\"2513\" data-end=\"2541\"\u003eResearch models examine how:\u003c\/p\u003e\n\u003cp data-start=\"2543\" data-end=\"2754\"\u003e• GLP-1R signaling influences nutrient-related feedback systems\u003cbr data-start=\"2606\" data-end=\"2609\"\u003e• GCGR activation affects lipid metabolism and mitochondrial activity\u003cbr data-start=\"2678\" data-end=\"2681\"\u003e• coordinated receptor activation impacts metabolic pathway integration\u003c\/p\u003e\n\u003cp data-start=\"2756\" data-end=\"2850\"\u003eThese pathways are explored in relation to complex endocrine and metabolic signaling networks.\u003c\/p\u003e\n\u003ch3 data-section-id=\"a2ux4l\" data-start=\"2857\" data-end=\"2896\"\u003eImportance of Balanced Dual Agonism\u003c\/h3\u003e\n\u003cp data-start=\"2898\" data-end=\"3022\"\u003eNative oxyntomodulin naturally interacts with both GLP-1R and GCGR but has limited stability and short duration of activity.\u003c\/p\u003e\n\u003cp data-start=\"3024\" data-end=\"3184\"\u003eMazdutide’s structural modifications enhance receptor interaction and signaling persistence while preserving balanced dual agonism across both receptor systems.\u003c\/p\u003e\n\u003cp data-start=\"3186\" data-end=\"3240\"\u003eThis balanced profile is studied for its influence on:\u003c\/p\u003e\n\u003cp data-start=\"3242\" data-end=\"3369\"\u003e• metabolic flexibility\u003cbr data-start=\"3265\" data-end=\"3268\"\u003e• mitochondrial energy signaling\u003cbr data-start=\"3300\" data-end=\"3303\"\u003e• lipid metabolism pathways\u003cbr data-start=\"3330\" data-end=\"3333\"\u003e• coordinated endocrine regulation\u003c\/p\u003e\n\u003ch3 data-section-id=\"1yoi1o1\" data-start=\"3376\" data-end=\"3437\"\u003eComparative Overview of Multi-Receptor Metabolic Peptides\u003c\/h3\u003e\n\u003ctable style=\"width: 100%;\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth style=\"width: 15.5235%;\"\u003eCompound\u003c\/th\u003e\n\u003cth style=\"width: 15.1625%;\"\u003eReceptors Targeted\u003c\/th\u003e\n\u003cth style=\"width: 14.2599%;\"\u003eAgonist Profile\u003c\/th\u003e\n\u003cth style=\"width: 11.9134%;\"\u003eCAS Number\u003c\/th\u003e\n\u003cth style=\"width: 19.8556%;\"\u003eResearch Stage\u003c\/th\u003e\n\u003cth style=\"width: 21.2996%;\"\u003eKey Research Focus\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 15.5235%;\"\u003eSemaglutide\u003c\/td\u003e\n\u003ctd style=\"width: 15.1625%;\"\u003eGLP-1R\u003c\/td\u003e\n\u003ctd style=\"width: 14.2599%;\"\u003eGLP-1R agonist\u003c\/td\u003e\n\u003ctd style=\"width: 11.9134%;\"\u003e910463-68-2\u003c\/td\u003e\n\u003ctd style=\"width: 19.8556%;\"\u003eApproved \/ extensively studied\u003c\/td\u003e\n\u003ctd style=\"width: 21.2996%;\"\u003eAppetite and incretin signaling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 15.5235%;\"\u003eTirzepatide\u003c\/td\u003e\n\u003ctd style=\"width: 15.1625%;\"\u003eGLP-1R + GIPR\u003c\/td\u003e\n\u003ctd style=\"width: 14.2599%;\"\u003eDual agonist\u003c\/td\u003e\n\u003ctd style=\"width: 11.9134%;\"\u003e2023788-19-2\u003c\/td\u003e\n\u003ctd style=\"width: 19.8556%;\"\u003eApproved \/ extensively studied\u003c\/td\u003e\n\u003ctd style=\"width: 21.2996%;\"\u003eMulti-incretin metabolic signaling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 15.5235%;\"\u003eRetatrutide\u003c\/td\u003e\n\u003ctd style=\"width: 15.1625%;\"\u003eGLP-1R + GIPR + GCGR\u003c\/td\u003e\n\u003ctd style=\"width: 14.2599%;\"\u003eTriple agonist\u003c\/td\u003e\n\u003ctd style=\"width: 11.9134%;\"\u003e2381089-83-2\u003c\/td\u003e\n\u003ctd style=\"width: 19.8556%;\"\u003eAdvanced clinical research\u003c\/td\u003e\n\u003ctd style=\"width: 21.2996%;\"\u003eMulti-receptor energy regulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 15.5235%;\"\u003eMazdutide\u003c\/td\u003e\n\u003ctd style=\"width: 15.1625%;\"\u003eGLP-1R + GCGR\u003c\/td\u003e\n\u003ctd style=\"width: 14.2599%;\"\u003eDual GLP-1R \/ GCGR agonist\u003c\/td\u003e\n\u003ctd style=\"width: 11.9134%;\"\u003e2259884-03-0\u003c\/td\u003e\n\u003ctd style=\"width: 19.8556%;\"\u003eApproved in China \/ ongoing research\u003c\/td\u003e\n\u003ctd style=\"width: 21.2996%;\"\u003eEnergy expenditure and metabolic signaling\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3 data-section-id=\"wv8cei\" data-start=\"4308\" data-end=\"4319\"\u003eSummary\u003c\/h3\u003e\n\u003cp data-start=\"4321\" data-end=\"4454\"\u003eMazdutide is a dual GLP-1R and GCGR agonist studied for its role in coordinated metabolic signaling and endocrine pathway regulation.\u003c\/p\u003e\n\u003cp data-start=\"4456\" data-end=\"4491\"\u003eIts mechanisms are associated with:\u003c\/p\u003e\n\u003cp data-start=\"4493\" data-end=\"4657\"\u003e• cAMP-mediated GPCR signaling\u003cbr data-start=\"4523\" data-end=\"4526\"\u003e• GLP-1 and glucagon receptor activation\u003cbr data-start=\"4566\" data-end=\"4569\"\u003e• mitochondrial and lipid metabolism pathways\u003cbr data-start=\"4614\" data-end=\"4617\"\u003e• integrated energy regulation systems\u003c\/p\u003e\n\u003cp data-start=\"4659\" data-end=\"4850\"\u003eAs a research peptide and metabolic signaling compound, mazdutide is explored to better understand how balanced multi-receptor activation influences complex biological and endocrine networks.\u003c\/p\u003e\n\u003cp data-start=\"4857\" data-end=\"4996\" data-is-last-node=\"\" data-is-only-node=\"\"\u003eAll information presented is based on experimental and clinical research data and is intended for scientific and educational purposes only.\u003c\/p\u003e","brand":"PRG","offers":[{"title":"Pre-filled Pen","offer_id":53000841068810,"sku":null,"price":195.0,"currency_code":"EUR","in_stock":true},{"title":"Vial","offer_id":53000841101578,"sku":null,"price":170.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Mazdutide_2.png?v=1778074824","url":"https:\/\/www.peptideregenesis.com\/products\/mazdutide-research-peptide","provider":"PRG","version":"1.0","type":"link"}