{"product_id":"kpv-10mg","title":"KPV 10mg – Research Peptide","description":"\u003ch3 data-start=\"393\" data-end=\"426\"\u003e\u003cstrong\u003eKPV Peptide – Research Overview\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"428\" data-end=\"723\"\u003eKPV is the C-terminal tripeptide fragment (amino acids 11–13) of the α-melanocyte-stimulating hormone (α-MSH) sequence. This short peptide retains key regulatory signaling characteristics associated with the parent hormone while lacking the melanotropic activity linked to pigmentation pathways.\u003c\/p\u003e\n\u003cp data-start=\"725\" data-end=\"916\"\u003eIn experimental literature, KPV is primarily examined for its interaction with inflammatory signaling networks, particularly pathways associated with NF-κB activation and cytokine regulation.\u003c\/p\u003e\n\u003ch3 data-start=\"923\" data-end=\"953\"\u003eMolecular Mechanism Research\u003c\/h3\u003e\n\u003cp data-start=\"955\" data-end=\"973\"\u003e\u003cstrong\u003eCellular Uptake\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"975\" data-end=\"1292\"\u003eIn experimental models involving intestinal epithelial and immune cells, KPV can be transported intracellularly via the \u003cstrong data-start=\"1095\" data-end=\"1138\"\u003ePepT1 (hPepT1) oligopeptide transporter\u003c\/strong\u003e. This transporter is often upregulated in inflamed intestinal tissues and facilitates the uptake of small di- and tripeptides across epithelial barriers.\u003c\/p\u003e\n\u003cp data-start=\"1294\" data-end=\"1447\"\u003eBecause of this transporter interaction, KPV is frequently investigated in research examining intestinal peptide absorption and mucosal immune signaling.\u003c\/p\u003e\n\u003cp data-start=\"1454\" data-end=\"1482\"\u003e\u003cstrong\u003eNF-κB Pathway Interaction\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"1484\" data-end=\"1680\"\u003eOne of the most widely discussed mechanisms of KPV in experimental literature involves its interaction with the \u003cstrong data-start=\"1596\" data-end=\"1623\"\u003eNF-κB signaling pathway\u003c\/strong\u003e, a central regulator of inflammatory gene transcription.\u003c\/p\u003e\n\u003cp data-start=\"1682\" data-end=\"1743\"\u003eResearch observations suggest several molecular interactions:\u003c\/p\u003e\n\u003cp data-start=\"1745\" data-end=\"1916\"\u003e• \u003cstrong data-start=\"1747\" data-end=\"1769\"\u003eIκBα stabilization\u003c\/strong\u003e – KPV has been associated with delayed degradation and accelerated recovery of IκBα, the inhibitory protein that retains NF-κB in the cytoplasm.\u003c\/p\u003e\n\u003cp data-start=\"1918\" data-end=\"2184\"\u003e• \u003cstrong data-start=\"1920\" data-end=\"1956\"\u003eNuclear translocation modulation\u003c\/strong\u003e – experimental data indicate that KPV may interfere with the interaction between the p65RelA NF-κB subunit and nuclear transport proteins such as importin-α3. This interaction can influence NF-κB nuclear translocation dynamics.\u003c\/p\u003e\n\u003cp data-start=\"2186\" data-end=\"2333\"\u003e• \u003cstrong data-start=\"2188\" data-end=\"2224\"\u003eReduced NF-κB signaling duration\u003c\/strong\u003e – rather than fully suppressing the pathway, KPV is associated with modulation of NF-κB activation dynamics.\u003c\/p\u003e\n\u003cp data-start=\"2335\" data-end=\"2454\"\u003eDownstream effects reported in experimental studies include changes in transcription of cytokine-related genes such as:\u003c\/p\u003e\n\u003cul data-start=\"2456\" data-end=\"2503\"\u003e\n\u003cli data-start=\"2456\" data-end=\"2465\"\u003e\n\u003cp data-start=\"2458\" data-end=\"2465\"\u003eTNF-α\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2466\" data-end=\"2475\"\u003e\n\u003cp data-start=\"2468\" data-end=\"2475\"\u003eIL-1β\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2476\" data-end=\"2484\"\u003e\n\u003cp data-start=\"2478\" data-end=\"2484\"\u003eIL-6\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2485\" data-end=\"2493\"\u003e\n\u003cp data-start=\"2487\" data-end=\"2493\"\u003eIL-8\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2494\" data-end=\"2503\"\u003e\n\u003cp data-start=\"2496\" data-end=\"2503\"\u003eMCP-1\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2505\" data-end=\"2619\"\u003eThese observations have made KPV a subject of interest in research examining cytokine-mediated signaling networks.\u003c\/p\u003e\n\u003ch3 data-start=\"2626\" data-end=\"2658\"\u003eAdditional Signaling Pathways\u003c\/h3\u003e\n\u003cp data-start=\"2660\" data-end=\"2799\"\u003eBeyond NF-κB-related signaling, some experimental models have reported interactions between KPV and \u003cstrong data-start=\"2760\" data-end=\"2787\"\u003eMAPK signaling cascades\u003c\/strong\u003e, including:\u003c\/p\u003e\n\u003cul data-start=\"2801\" data-end=\"2827\"\u003e\n\u003cli data-start=\"2801\" data-end=\"2811\"\u003e\n\u003cp data-start=\"2803\" data-end=\"2811\"\u003eERK1\/2\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2812\" data-end=\"2819\"\u003e\n\u003cp data-start=\"2814\" data-end=\"2819\"\u003eJNK\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2820\" data-end=\"2827\"\u003e\n\u003cp data-start=\"2822\" data-end=\"2827\"\u003ep38\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2829\" data-end=\"2976\"\u003eThese pathways are frequently investigated in studies examining cellular stress responses, cytokine signaling, and inflammatory pathway regulation.\u003c\/p\u003e\n\u003cp data-start=\"2978\" data-end=\"3217\"\u003eIn certain cell systems, particularly airway or skin models, limited evidence suggests involvement of melanocortin receptors such as \u003cstrong data-start=\"3111\" data-end=\"3119\"\u003eMC3R\u003c\/strong\u003e, although many reported effects appear independent of classical melanocortin receptor activation.\u003c\/p\u003e\n\u003ch3 data-start=\"3224\" data-end=\"3255\"\u003eExperimental Research Context\u003c\/h3\u003e\n\u003cp data-start=\"3257\" data-end=\"3290\"\u003e\u003cstrong\u003eIntestinal Inflammation Models\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"3292\" data-end=\"3565\"\u003eKPV is frequently investigated in preclinical intestinal inflammation models, including DSS and TNBS-induced colitis systems. In these models, experimental observations have reported changes in cytokine signaling, neutrophil infiltration, and inflammatory pathway activity.\u003c\/p\u003e\n\u003cp data-start=\"3567\" data-end=\"3684\"\u003eBecause KPV interacts with the PepT1 transporter in intestinal tissue, it is commonly examined in research exploring:\u003c\/p\u003e\n\u003cul data-start=\"3686\" data-end=\"3812\"\u003e\n\u003cli data-start=\"3686\" data-end=\"3718\"\u003e\n\u003cp data-start=\"3688\" data-end=\"3718\"\u003eepithelial barrier signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3719\" data-end=\"3748\"\u003e\n\u003cp data-start=\"3721\" data-end=\"3748\"\u003emucosal immune regulation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3749\" data-end=\"3781\"\u003e\n\u003cp data-start=\"3751\" data-end=\"3781\"\u003eintestinal cytokine networks\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3782\" data-end=\"3812\"\u003e\n\u003cp data-start=\"3784\" data-end=\"3812\"\u003epeptide transporter dynamics\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"3819\" data-end=\"3862\"\u003e\u003cstrong\u003eSkin and Cellular Inflammatory Signaling\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"3864\" data-end=\"4013\"\u003eCell culture studies have reported that KPV can influence \u003cstrong data-start=\"3922\" data-end=\"3972\"\u003eTNF-α-mediated signaling and ICAM-1 expression\u003c\/strong\u003e in dermal fibroblasts and keratinocytes.\u003c\/p\u003e\n\u003cp data-start=\"4015\" data-end=\"4148\"\u003eThese mechanisms are typically examined in laboratory models studying inflammatory signaling pathways in skin and epithelial tissues.\u003c\/p\u003e\n\u003cp data-start=\"4155\" data-end=\"4197\"\u003e\u003cstrong\u003eNeuroimmune and Gut–Brain Axis Research\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-start=\"4199\" data-end=\"4328\"\u003eInteractions between intestinal immune signaling and the nervous system are increasingly investigated in gut–brain axis research.\u003c\/p\u003e\n\u003cp data-start=\"4330\" data-end=\"4645\"\u003eChanges in cytokine signaling and epithelial barrier dynamics may influence vagal nerve pathways and systemic inflammatory signaling. Within this framework, peptides derived from melanocortin signaling systems, including KPV, are occasionally examined in experimental models investigating neuroimmune communication.\u003c\/p\u003e\n\u003ch3 data-start=\"4652\" data-end=\"4685\"\u003eTransport and Delivery Research\u003c\/h3\u003e\n\u003cp data-start=\"4687\" data-end=\"4879\"\u003eDue to its small tripeptide structure, KPV is capable of interacting with peptide transport systems such as \u003cstrong data-start=\"4795\" data-end=\"4804\"\u003ePepT1\u003c\/strong\u003e, which mediates the uptake of small peptides in the intestinal epithelium.\u003c\/p\u003e\n\u003cp data-start=\"4881\" data-end=\"5034\"\u003eFor this reason, oral capsule formats are often used in experimental settings investigating intestinal peptide transport and localized mucosal signaling.\u003c\/p\u003e\n\u003ch3 style=\"margin-bottom: 0cm;\"\u003eUnderstand KPV in Gut and Inflammation Research\u003c\/h3\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e \u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003eKPV is widely studied in research models focused on inflammation signaling and epithelial cellular environments, particularly within gut-associated systems. Its interaction with pathways such as NF-κB makes it relevant in studies exploring how localized inflammation and cellular communication are regulated.\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003eTo see how KPV is examined alongside other compounds in gut and immune signaling research:\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/gut-health-and-inflammation-kpv-bpc-157-thymosin-alpha-1\"\u003e\u003cstrong\u003eGut Health and Inflammation Research: KPV, BPC-157, and Thymosin Alpha-1\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e \u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003eFor a deeper scientific overview of its mechanism, pathways, and research applications:\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e\u003cstrong\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/gut-health-and-inflammation-kpv-bpc-157-thymosin-alpha-1\"\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/what-is-kpv\"\u003eWhat is KPV? - NF-κB Signaling and Inflammation Research Explained\u003c\/a\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp style=\"margin-bottom: 0cm;\"\u003e \u003c\/p\u003e\n\u003ch3 data-start=\"5041\" data-end=\"5062\"\u003eProduct Information\u003c\/h3\u003e\n\u003cp data-start=\"5064\" data-end=\"5213\"\u003e\u003cstrong data-start=\"5064\" data-end=\"5077\"\u003eSynonyms:\u003c\/strong\u003e Lys-Pro-Val peptide, KPV peptide\u003cbr data-start=\"5138\" data-end=\"5141\"\u003e\u003cstrong data-start=\"5141\" data-end=\"5163\"\u003eMolecular Formula:\u003c\/strong\u003e \u003cspan\u003eC\u003c\/span\u003e\u003csub\u003e16\u003c\/sub\u003e\u003cspan\u003eH\u003c\/span\u003e\u003csub\u003e30\u003c\/sub\u003e\u003cspan\u003eN\u003c\/span\u003e\u003csub\u003e4\u003c\/sub\u003e\u003cspan\u003eO\u003c\/span\u003e\u003csub\u003e4\u003c\/sub\u003e\u003cbr data-start=\"5174\" data-end=\"5177\"\u003e\u003cstrong data-start=\"5177\" data-end=\"5198\"\u003eMolecular Weight:\u003c\/strong\u003e \u003cspan\u003e342.43\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan\u003eg\/mol\u003cbr\u003e\u003cstrong\u003eCAS: \u003c\/strong\u003e67727-97-3\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-start=\"5220\" data-end=\"5261\"\u003eResearch Areas Referenced in Literature\u003c\/h3\u003e\n\u003cp data-start=\"5263\" data-end=\"5318\"\u003eExperimental studies have discussed KPV in relation to:\u003c\/p\u003e\n\u003cul data-start=\"5320\" data-end=\"5525\"\u003e\n\u003cli data-start=\"5320\" data-end=\"5348\"\u003e\n\u003cp data-start=\"5322\" data-end=\"5348\"\u003eNF-κB signaling pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5349\" data-end=\"5381\"\u003e\n\u003cp data-start=\"5351\" data-end=\"5381\"\u003ecytokine regulation networks\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5382\" data-end=\"5412\"\u003e\n\u003cp data-start=\"5384\" data-end=\"5412\"\u003eepithelial barrier biology\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5413\" data-end=\"5455\"\u003e\n\u003cp data-start=\"5415\" data-end=\"5455\"\u003emelanocortin-related peptide signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5456\" data-end=\"5490\"\u003e\n\u003cp data-start=\"5458\" data-end=\"5490\"\u003eintestinal transporter systems\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5491\" data-end=\"5525\"\u003e\n\u003cp data-start=\"5493\" data-end=\"5525\"\u003eneuroimmune communication models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eKPV Structures: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv style=\"text-align: left;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Kpv_structure.png?v=1772702715\" alt=\"KPV peptide Structures\" style=\"margin-bottom: 16px; float: none;\"\u003e\u003c\/div\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/125672\"\u003eSource: PubChem\u003c\/a\u003e\u003c\/p\u003e","brand":"PRG","offers":[{"title":"Vial","offer_id":52641930707210,"sku":null,"price":130.0,"currency_code":"EUR","in_stock":true},{"title":"Pre-filled Pen ( 1 )","offer_id":52641930739978,"sku":null,"price":155.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/KPV10mg_2.png?v=1772291130","url":"https:\/\/www.peptideregenesis.com\/products\/kpv-10mg","provider":"PRG","version":"1.0","type":"link"}