{"product_id":"epithalon-25mg","title":"Epithalon 25mg – Research Peptide","description":"\u003ch3 data-section-id=\"178uri\" data-start=\"443\" data-end=\"503\"\u003eEpithalon – Telomere and Pineal Signaling Research Peptide\u003c\/h3\u003e\n\u003ch3 data-section-id=\"rzkdgm\" data-start=\"505\" data-end=\"516\"\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"518\" data-end=\"847\"\u003eEpithalon (also spelled Epitalon or Epithalone) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). The peptide was originally developed by Professor Vladimir Khavinson and colleagues based on the amino acid composition of epithalamin, a natural peptide complex derived from the pineal gland.\u003c\/p\u003e\n\u003cp data-start=\"849\" data-end=\"1051\"\u003eIn research settings, Epithalon is frequently studied for its interaction with cellular aging pathways, telomere regulation, and neuroendocrine signaling mechanisms associated with the pineal gland.\u003c\/p\u003e\n\u003cp data-start=\"1053\" data-end=\"1337\"\u003eDue to its small molecular size (≈390 Da), Epithalon demonstrates high cellular permeability and has been observed in laboratory models to interact with intracellular targets including DNA binding motifs, histone complexes, and amino acid transport systems such as LAT1 and PEPT1.\u003c\/p\u003e\n\u003cp data-start=\"1339\" data-end=\"1519\"\u003eThese characteristics have made the peptide a subject of investigation in studies exploring epigenetic regulation, cellular longevity pathways, and circadian signaling systems.\u003c\/p\u003e\n\u003cp data-start=\"1649\" data-end=\"1813\"\u003eEpithalon is a short tetrapeptide capable of entering cells and interacting with nuclear regulatory elements involved in gene expression and chromatin organization.\u003c\/p\u003e\n\u003cp data-start=\"1815\" data-end=\"2040\"\u003eExperimental models have suggested that the peptide may interact with specific DNA binding motifs, including sequences such as ATTTC and CAG, potentially influencing transcriptional regulation and chromatin accessibility.\u003c\/p\u003e\n\u003ch3 data-section-id=\"10gl7hx\" data-start=\"2047\" data-end=\"2093\"\u003eCellular Mechanisms Investigated in Research\u003c\/h3\u003e\n\u003cp data-start=\"2095\" data-end=\"2222\"\u003eMultiple studies in human cell cultures and in vitro systems have explored several biological pathways influenced by Epithalon.\u003c\/p\u003e\n\u003ch3 data-section-id=\"hkl10f\" data-start=\"2224\" data-end=\"2273\"\u003eTelomerase Activation and Telomere Regulation\u003c\/h3\u003e\n\u003cp data-start=\"2275\" data-end=\"2521\"\u003eIn laboratory studies involving telomerase-negative human fibroblasts, Epithalon exposure has been associated with increased expression of the hTERT catalytic subunit, along with measurable telomerase enzymatic activity using TRAP assays.\u003c\/p\u003e\n\u003cp data-start=\"2523\" data-end=\"2725\"\u003eThese findings were accompanied by measurable changes in telomere length and cellular replicative lifespan, suggesting that the peptide may influence mechanisms associated with telomere maintenance.\u003c\/p\u003e\n\u003cp data-start=\"2727\" data-end=\"2955\"\u003eSimilar observations have been reported in lymphocyte models and additional human cell lines, where Epithalon exposure was associated with activation of telomerase-related pathways or alternative telomere lengthening mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"2957\" data-end=\"3101\"\u003eThese findings have positioned Epithalon as a compound frequently examined in research focused on cellular senescence and genomic stability.\u003c\/p\u003e\n\u003ch3 data-section-id=\"1vk4t1c\" data-start=\"3108\" data-end=\"3153\"\u003ePineal Signaling and Circadian Regulation\u003c\/h3\u003e\n\u003cp data-start=\"3155\" data-end=\"3250\"\u003eThe peptide has also been studied for its interaction with pineal gland signaling pathways.\u003c\/p\u003e\n\u003cp data-start=\"3252\" data-end=\"3474\"\u003eExperimental research indicates that Epithalon may influence biochemical pathways associated with serotonin, N-acetylserotonin, and melatonin synthesis, molecules that play central roles in circadian rhythm regulation.\u003c\/p\u003e\n\u003cp data-start=\"3476\" data-end=\"3668\"\u003eAnimal models have reported restoration of melatonin rhythmicity and circadian hormone patterns in aged organisms following exposure to pineal peptides including Epithalon and epithalamin.\u003c\/p\u003e\n\u003cp data-start=\"3670\" data-end=\"3820\"\u003eHuman studies exploring pineal signaling have also observed increased melatonin-related markers and modulation of circadian clock gene expression.\u003c\/p\u003e\n\u003cp data-start=\"3822\" data-end=\"3948\"\u003eThese findings have led to interest in Epithalon within studies examining circadian biology and neuroendocrine regulation.\u003c\/p\u003e\n\u003ch3 data-section-id=\"6dtfz0\" data-start=\"3955\" data-end=\"4000\"\u003eAntioxidant and Cellular Stress Signaling\u003c\/h3\u003e\n\u003cp data-start=\"4002\" data-end=\"4089\"\u003eEpithalon has been investigated in research models examining oxidative stress pathways.\u003c\/p\u003e\n\u003cp data-start=\"4091\" data-end=\"4146\"\u003eExperimental findings have associated the peptide with:\u003c\/p\u003e\n\u003cul data-start=\"4148\" data-end=\"4361\"\u003e\n\u003cli data-section-id=\"fzci8c\" data-start=\"4148\" data-end=\"4201\"\u003e\n\u003cp data-start=\"4150\" data-end=\"4201\"\u003ereduced levels of reactive oxygen species (ROS)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"1d5dk6f\" data-start=\"4202\" data-end=\"4240\"\u003e\n\u003cp data-start=\"4204\" data-end=\"4240\"\u003edecreased lipid peroxidation markers\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-section-id=\"f8zrky\" data-start=\"4241\" data-end=\"4361\"\u003e\n\u003cp data-start=\"4243\" data-end=\"4361\"\u003eactivation of cellular antioxidant systems including Nrf2, superoxide dismutase (SOD), catalase, and ceruloplasmin\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"4363\" data-end=\"4522\"\u003eSeveral studies have also examined the peptide’s influence on p53-related signaling, a pathway involved in genomic stability and cellular stress responses.\u003c\/p\u003e\n\u003ch3 data-section-id=\"5luq3p\" data-start=\"4529\" data-end=\"4565\"\u003eImmune and Epigenetic Regulation\u003c\/h3\u003e\n\u003cp data-start=\"4567\" data-end=\"4728\"\u003eResearch exploring immune signaling has suggested that Epithalon may influence thymic signaling pathways and T-lymphocyte maturation in experimental systems.\u003c\/p\u003e\n\u003cp data-start=\"4730\" data-end=\"4975\"\u003eAt the chromatin level, studies have reported changes in heterochromatin condensation states, suggesting that Epithalon may influence gene expression by altering chromatin accessibility and reactivating genes that become suppressed with age.\u003c\/p\u003e\n\u003cp data-start=\"4977\" data-end=\"5127\"\u003eThese epigenetic observations have led to increased interest in Epithalon in research investigating cellular aging and transcriptional regulation.\u003c\/p\u003e\n\u003ch3 data-section-id=\"1nisyld\" data-start=\"5134\" data-end=\"5165\"\u003ePreclinical Research Findings\u003c\/h3\u003e\n\u003cp data-start=\"5167\" data-end=\"5313\"\u003eExtensive experimental work has investigated Epithalon in a variety of biological models including mice, rats, primates, and invertebrate systems.\u003c\/p\u003e\n\u003cp data-start=\"5315\" data-end=\"5374\"\u003eResearch has explored several biological domains including:\u003c\/p\u003e\n\u003ch3 data-section-id=\"nipbeu\" data-start=\"5376\" data-end=\"5415\"\u003eLongevity and Cellular Aging Models\u003c\/h3\u003e\n\u003cp data-start=\"5417\" data-end=\"5562\"\u003eAnimal studies have reported measurable changes in lifespan markers and age-associated biological parameters following exposure to Epithalon.\u003c\/p\u003e\n\u003cp data-start=\"5564\" data-end=\"5747\"\u003eFor example, experiments in Drosophila and rodent models reported increases in mean and maximal lifespan, along with delayed onset of certain age-associated physiological changes.\u003c\/p\u003e\n\u003cp data-start=\"5749\" data-end=\"5869\"\u003eAdditional studies have observed reductions in chromosomal abnormalities and preservation of cellular genomic stability.\u003c\/p\u003e\n\u003ch3 data-section-id=\"1itszh3\" data-start=\"5876\" data-end=\"5902\"\u003eTumor Biology Research\u003c\/h3\u003e\n\u003cp data-start=\"5904\" data-end=\"5995\"\u003ePreclinical research has examined Epithalon in models of chemically induced carcinogenesis.\u003c\/p\u003e\n\u003cp data-start=\"5997\" data-end=\"6234\"\u003eIn certain experimental systems, Epithalon exposure was associated with changes in tumor incidence, tumor multiplicity, and gene expression markers linked to tumor signaling pathways, including HER-2 related transcriptional activity.\u003c\/p\u003e\n\u003cp data-start=\"6236\" data-end=\"6361\"\u003eThese studies are frequently cited in research exploring cellular stress responses, genomic stability, and tumor biology.\u003c\/p\u003e\n\u003ch3 data-section-id=\"jbg307\" data-start=\"6368\" data-end=\"6404\"\u003eAntioxidant and Immune Signaling\u003c\/h3\u003e\n\u003cp data-start=\"6406\" data-end=\"6598\"\u003eExperimental investigations have reported that Epithalon may influence oxidative stress markers and immune cell populations, including T- and B-lymphocyte activity and antibody production.\u003c\/p\u003e\n\u003cp data-start=\"6600\" data-end=\"6756\"\u003eThe peptide has also been studied in models examining pineal-immune interactions and the relationship between circadian signaling and immune regulation.\u003c\/p\u003e\n\u003ch3 data-section-id=\"11i1ubz\" data-start=\"6763\" data-end=\"6806\"\u003eNeural and Reproductive Research Models\u003c\/h3\u003e\n\u003cp data-start=\"6808\" data-end=\"6917\"\u003eAdditional research has explored Epithalon’s influence on neurological signaling and reproductive physiology.\u003c\/p\u003e\n\u003cp data-start=\"6919\" data-end=\"7113\"\u003eAnimal studies have reported measurable changes in learning behavior, neuronal stress resistance, mitochondrial function in reproductive cells, and chromatin activation in aging lymphocytes.\u003c\/p\u003e\n\u003cp data-start=\"7115\" data-end=\"7271\"\u003eThese findings have contributed to interest in Epithalon within studies investigating neurobiology, reproductive biology, and cellular stress responses.\u003c\/p\u003e\n\u003ch3 data-section-id=\"ep46tr\" data-start=\"7278\" data-end=\"7305\"\u003eClinical Research Context\u003c\/h3\u003e\n\u003cp data-start=\"7307\" data-end=\"7508\"\u003eClinical investigations of pineal peptides including epithalamin and Epithalon analogs have explored their influence on circadian signaling, immune markers, and age-related physiological processes.\u003c\/p\u003e\n\u003cp data-start=\"7510\" data-end=\"7722\"\u003eStudies involving elderly populations have reported measurable changes in melatonin signaling, chromatin activation in lymphocytes, and immune system markers following exposure to pineal peptide preparations.\u003c\/p\u003e\n\u003cp data-start=\"7724\" data-end=\"7909\"\u003eAdditional clinical research examining retinal disorders reported improvements in visual function parameters following administration of pineal peptides in controlled clinical settings.\u003c\/p\u003e\n\u003cp data-start=\"7911\" data-end=\"8066\"\u003eThese studies have contributed to ongoing interest in Epithalon in research focused on circadian biology, cellular aging, and pineal hormone signaling.\u003c\/p\u003e\n\u003ch3 data-section-id=\"1yxgta6\" data-start=\"8073\" data-end=\"8112\"\u003eSafety Profile in Research Literature\u003c\/h3\u003e\n\u003cp data-start=\"8114\" data-end=\"8308\"\u003eAcross experimental and clinical research programs, Epithalon has demonstrated a favorable safety profile, with studies reporting no significant genotoxic, nephrotoxic, or mutagenic effects.\u003c\/p\u003e\n\u003cp data-start=\"8310\" data-end=\"8512\"\u003eLong-term animal studies and clinical observations have reported good tolerability, supporting continued investigation of the peptide in research exploring aging biology and cellular signaling pathways.\u003c\/p\u003e\n\u003ch3\u003eResearch context\u003c\/h3\u003e\n\u003cp\u003eEpithalon is frequently referenced in experimental models examining cellular homeostasis, telomere dynamics, and circadian signaling pathways. These research frameworks explore how gene expression, metabolic balance, and regulatory systems interact to support long-term cellular stability.\u003c\/p\u003e\n\u003cp\u003eFor a broader overview of how peptides and small molecules are studied in health maintenance and longevity-related research models, see:\u003c\/p\u003e\n\u003cp\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/cellular-homeostasis-research\"\u003eCellular Homeostasis \u0026amp; Health Maintenance Research\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch3 data-start=\"2257\" data-end=\"2577\"\u003e\u003cstrong data-start=\"2257\" data-end=\"2280\"\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp data-start=\"2257\" data-end=\"2577\"\u003e\u003cstrong data-start=\"2283\" data-end=\"2296\"\u003eSynonyms:\u003c\/strong\u003e  Epithalon, Epithalone, UNII-O65P17785G, alanyl-glutamyl-aspartyl-glycine\u003cbr data-start=\"2382\" data-end=\"2385\"\u003e\u003cstrong data-start=\"2385\" data-end=\"2407\"\u003eMolecular Formula:\u003c\/strong\u003e \u003cspan\u003eC\u003c\/span\u003e\u003csub\u003e14\u003c\/sub\u003e\u003cspan\u003eH\u003c\/span\u003e\u003csub\u003e22\u003c\/sub\u003e\u003cspan\u003eN\u003c\/span\u003e\u003csub\u003e4\u003c\/sub\u003e\u003cspan\u003eO\u003c\/span\u003e\u003csub\u003e9\u003c\/sub\u003e\u003cbr data-start=\"2418\" data-end=\"2421\"\u003e\u003cstrong data-start=\"2421\" data-end=\"2436\"\u003eMolar Mass:\u003c\/strong\u003e 390.35 g\/mol\u003cbr data-start=\"2449\" data-end=\"2452\"\u003e\u003cstrong data-start=\"2452\" data-end=\"2467\"\u003eCAS Number:\u003c\/strong\u003e \u003cspan\u003e307297-39-8\u003c\/span\u003e\u003cbr data-start=\"2479\" data-end=\"2482\"\u003e\u003cstrong data-start=\"2482\" data-end=\"2494\"\u003ePubChem:\u003c\/strong\u003e 219042\u003cbr data-start=\"2501\" data-end=\"2504\"\u003e\u003cstrong data-start=\"2504\" data-end=\"2532\"\u003eTotal Active Ingredient:\u003c\/strong\u003e 25 mg (1 vial)\u003c\/p\u003e\n\u003ch3 data-start=\"2257\" data-end=\"2577\"\u003eEpithalon \u003cspan\u003eStructures:\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Epitalon.png?v=1755244759\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSource \u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/219042\" title=\"PubChem_Epithalon\"\u003ePubChem\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"PRG","offers":[{"title":"Vial","offer_id":52642219196682,"sku":"epithalon25mg-1","price":130.0,"currency_code":"EUR","in_stock":true},{"title":"Pre-filled Pen ( 1 )","offer_id":52642219229450,"sku":"epithalon25mg-2","price":155.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/epithalon_25mg_2.png?v=1773049932","url":"https:\/\/www.peptideregenesis.com\/products\/epithalon-25mg","provider":"PRG","version":"1.0","type":"link"}