{"product_id":"dsip-5mg","title":"DSIP (Acetate) 5mg – Research Peptide","description":"\u003ch3 data-start=\"760\" data-end=\"817\"\u003eDSIP (Delta Sleep-Inducing Peptide) – Research Overview\u003c\/h3\u003e\n\u003cp data-start=\"819\" data-end=\"1168\"\u003eDSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide studied in experimental research examining sleep-related neurophysiology, circadian signaling, and neuroendocrine regulation. Laboratory models frequently investigate its interaction with stress-associated pathways, neurotransmitter systems, and slow-wave sleep architecture.\u003c\/p\u003e\n\u003cp data-start=\"1170\" data-end=\"1254\"\u003e \u003c\/p\u003e\n\u003cp data-start=\"1366\" data-end=\"1622\"\u003eThe peptide was originally isolated in the 1970s from cerebral venous blood of sleeping rabbits during electrophysiological studies of sleep states. Subsequent research identified similar peptide immunoreactivity in mammalian tissues, including human milk.\u003c\/p\u003e\n\u003cp data-start=\"1624\" data-end=\"1763\"\u003eExperimental observations suggest that DSIP levels follow a \u003cstrong data-start=\"1684\" data-end=\"1704\"\u003ecircadian rhythm\u003c\/strong\u003e, with measurable fluctuations across the sleep–wake cycle.\u003c\/p\u003e\n\u003ch3 data-start=\"1770\" data-end=\"1808\"\u003eDistribution and Endogenous Presence\u003c\/h3\u003e\n\u003cp data-start=\"1810\" data-end=\"1918\"\u003eDSIP-related peptide activity has been detected in several regions of the central nervous system, including:\u003c\/p\u003e\n\u003cul data-start=\"1920\" data-end=\"1998\"\u003e\n\u003cli data-start=\"1920\" data-end=\"1932\"\u003e\n\u003cp data-start=\"1922\" data-end=\"1932\"\u003ethalamus\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1933\" data-end=\"1952\"\u003e\n\u003cp data-start=\"1935\" data-end=\"1952\"\u003ecerebral cortex\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1953\" data-end=\"1967\"\u003e\n\u003cp data-start=\"1955\" data-end=\"1967\"\u003ecerebellum\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1968\" data-end=\"1984\"\u003e\n\u003cp data-start=\"1970\" data-end=\"1984\"\u003ehypothalamus\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1985\" data-end=\"1998\"\u003e\n\u003cp data-start=\"1987\" data-end=\"1998\"\u003ebrainstem\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2000\" data-end=\"2209\"\u003eAlthough the peptide has been studied for decades, \u003cstrong data-start=\"2051\" data-end=\"2136\"\u003eno dedicated precursor gene or specific receptor has been definitively identified\u003c\/strong\u003e, suggesting its activity may involve broader neuromodulatory mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"2211\" data-end=\"2361\"\u003eDSIP is also reported to \u003cstrong data-start=\"2236\" data-end=\"2269\"\u003ecross the blood–brain barrier\u003c\/strong\u003e, enabling investigation of central nervous system signaling effects in experimental models.\u003c\/p\u003e\n\u003ch3 data-start=\"2368\" data-end=\"2402\"\u003eMolecular and Cellular Signaling\u003c\/h3\u003e\n\u003cp data-start=\"2404\" data-end=\"2529\"\u003eResearch suggests that DSIP acts through \u003cstrong data-start=\"2445\" data-end=\"2528\"\u003emulti-system neuromodulatory interactions rather than a single receptor pathway\u003c\/strong\u003e.\u003c\/p\u003e\n\u003ch3 data-start=\"2531\" data-end=\"2554\"\u003eGlutamatergic System\u003c\/h3\u003e\n\u003cp data-start=\"2556\" data-end=\"2917\"\u003eExperimental models indicate that DSIP may influence \u003cstrong data-start=\"2609\" data-end=\"2649\"\u003eNMDA-related glutamatergic signaling\u003c\/strong\u003e. Studies have reported reductions in NMDA-activated neuronal currents in several brain regions, including the cortex, hippocampus, thalamus, and hypothalamus. These observations are associated with changes in intracellular calcium signaling and neuronal excitability.\u003c\/p\u003e\n\u003ch3 data-start=\"2924\" data-end=\"2946\"\u003eGABAergic Signaling\u003c\/h3\u003e\n\u003cp data-start=\"2948\" data-end=\"3155\"\u003eLaboratory studies have reported that DSIP can modulate \u003cstrong data-start=\"3004\" data-end=\"3049\"\u003eGABA-related inhibitory neurotransmission\u003c\/strong\u003e, including increased GABA-activated currents in neuronal models such as hippocampal and cerebellar cells.\u003c\/p\u003e\n\u003cp data-start=\"3157\" data-end=\"3291\"\u003eThese observations suggest a role for DSIP in research examining inhibitory–excitatory balance within central nervous system circuits.\u003c\/p\u003e\n\u003ch3 data-start=\"3298\" data-end=\"3331\"\u003eOpioid and Endorphin Signaling\u003c\/h3\u003e\n\u003cp data-start=\"3333\" data-end=\"3611\"\u003eSome experimental studies have reported interactions between DSIP signaling and \u003cstrong data-start=\"3413\" data-end=\"3442\"\u003eendogenous opioid systems\u003c\/strong\u003e, including changes in central endorphin activity. In certain models, opioid receptor antagonists have been observed to modify DSIP-related neurophysiological responses.\u003c\/p\u003e\n\u003ch3 data-start=\"3618\" data-end=\"3646\"\u003eNeuroendocrine Regulation\u003c\/h3\u003e\n\u003cp data-start=\"3648\" data-end=\"3747\"\u003eDSIP has also been examined in experimental models investigating neuroendocrine signaling pathways.\u003c\/p\u003e\n\u003cp data-start=\"3749\" data-end=\"3854\"\u003eReported interactions include modulation of hypothalamic and pituitary signaling systems associated with:\u003c\/p\u003e\n\u003cul data-start=\"3856\" data-end=\"4078\"\u003e\n\u003cli data-start=\"3856\" data-end=\"3896\"\u003e\n\u003cp data-start=\"3858\" data-end=\"3896\"\u003ecorticotropin-releasing factor (CRF)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3897\" data-end=\"3935\"\u003e\n\u003cp data-start=\"3899\" data-end=\"3935\"\u003eadrenocorticotropic hormone (ACTH)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3936\" data-end=\"3977\"\u003e\n\u003cp data-start=\"3938\" data-end=\"3977\"\u003egonadotropin-releasing hormone (GnRH)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"3978\" data-end=\"4006\"\u003e\n\u003cp data-start=\"3980\" data-end=\"4006\"\u003eluteinizing hormone (LH)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4007\" data-end=\"4044\"\u003e\n\u003cp data-start=\"4009\" data-end=\"4044\"\u003ethyroid-stimulating hormone (TSH)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4045\" data-end=\"4078\"\u003e\n\u003cp data-start=\"4047\" data-end=\"4078\"\u003egrowth hormone–related pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"4080\" data-end=\"4203\"\u003eThese pathways are frequently investigated in research exploring stress physiology and circadian neuroendocrine regulation.\u003c\/p\u003e\n\u003ch3 data-start=\"4210\" data-end=\"4250\"\u003eNeurotransmitter and Monoamine Systems\u003c\/h3\u003e\n\u003cp data-start=\"4252\" data-end=\"4350\"\u003eExperimental observations suggest DSIP may influence multiple neurotransmitter systems, including:\u003c\/p\u003e\n\u003cul data-start=\"4352\" data-end=\"4465\"\u003e\n\u003cli data-start=\"4352\" data-end=\"4378\"\u003e\n\u003cp data-start=\"4354\" data-end=\"4378\"\u003edopaminergic signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4379\" data-end=\"4402\"\u003e\n\u003cp data-start=\"4381\" data-end=\"4402\"\u003eadrenergic pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4403\" data-end=\"4429\"\u003e\n\u003cp data-start=\"4405\" data-end=\"4429\"\u003eserotonergic signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4430\" data-end=\"4465\"\u003e\n\u003cp data-start=\"4432\" data-end=\"4465\"\u003ehistamine-related neural pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"4467\" data-end=\"4591\"\u003eChanges in neuropeptides such as \u003cstrong data-start=\"4500\" data-end=\"4515\"\u003esubstance P\u003c\/strong\u003e and \u003cstrong data-start=\"4520\" data-end=\"4535\"\u003eβ-endorphin\u003c\/strong\u003e have also been reported in certain experimental models.\u003c\/p\u003e\n\u003ch3 data-start=\"4598\" data-end=\"4649\"\u003eOxidative Stress and Cellular Protection Pathways\u003c\/h3\u003e\n\u003cp data-start=\"4651\" data-end=\"4777\"\u003eSeveral studies examining neuronal stress models have reported that DSIP may influence antioxidant enzyme activity, including:\u003c\/p\u003e\n\u003cul data-start=\"4779\" data-end=\"4879\"\u003e\n\u003cli data-start=\"4779\" data-end=\"4811\"\u003e\n\u003cp data-start=\"4781\" data-end=\"4811\"\u003eglutathione peroxidase (GPx)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4812\" data-end=\"4842\"\u003e\n\u003cp data-start=\"4814\" data-end=\"4842\"\u003esuperoxide dismutase (SOD)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4843\" data-end=\"4855\"\u003e\n\u003cp data-start=\"4845\" data-end=\"4855\"\u003ecatalase\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"4856\" data-end=\"4879\"\u003e\n\u003cp data-start=\"4858\" data-end=\"4879\"\u003eglutathione reductase\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"4881\" data-end=\"5029\"\u003eThese mechanisms are often investigated in experimental models studying oxidative stress, mitochondrial function, and neuronal metabolic regulation.\u003c\/p\u003e\n\u003ch3 data-start=\"5036\" data-end=\"5067\"\u003eBlood–Brain Barrier Transport\u003c\/h3\u003e\n\u003cp data-start=\"5069\" data-end=\"5262\"\u003eExperimental research suggests DSIP may utilize \u003cstrong data-start=\"5117\" data-end=\"5189\"\u003ecarrier-mediated transport mechanisms across the blood–brain barrier\u003c\/strong\u003e, including potential involvement of the choroid plexus transport system.\u003c\/p\u003e\n\u003cp data-start=\"5264\" data-end=\"5393\"\u003eSuch mechanisms are frequently studied in research examining neuropeptide transport and central nervous system peptide signaling.\u003c\/p\u003e\n\u003cp data-start=\"5264\" data-end=\"5393\"\u003e \u003c\/p\u003e\n\u003ch3 data-start=\"5400\" data-end=\"5421\"\u003eProduct Information\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong data-start=\"5423\" data-end=\"5436\"\u003eSynonyms:\u003c\/strong\u003e Delta Sleep-Inducing Peptide, DSIP\u003c\/p\u003e\n\u003cp\u003e\u003cstrong data-start=\"5474\" data-end=\"5487\"\u003eSequence:\u003c\/strong\u003e Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu\u003c\/p\u003e\n\u003cp\u003e\u003cstrong data-start=\"5562\" data-end=\"5583\"\u003eMolecular Weight:\u003c\/strong\u003e ~848.8–849 Da\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003c\/span\u003e\u003cspan\u003eC\u003csub\u003e35\u003c\/sub\u003eH\u003csub\u003e48\u003c\/sub\u003eN\u003csub\u003e10\u003c\/sub\u003eO\u003csub\u003e15\u003c\/sub\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCAS: \u003c\/strong\u003e\u003cspan\u003e62568-57-4\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eTotal Active Ingredient:\u003c\/strong\u003e 5 mg per vial - ( Vial format: lyophilized powder for enhanced stability.)\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eResearch Areas Referenced in Scientific Literature\u003c\/h3\u003e\n\u003cul\u003e\u003c\/ul\u003e\n\u003cp data-start=\"5683\" data-end=\"5750\"\u003eDSIP is commonly referenced in experimental research investigating:\u003c\/p\u003e\n\u003cul data-start=\"5752\" data-end=\"6009\"\u003e\n\u003cli data-start=\"5752\" data-end=\"5804\"\u003e\n\u003cp data-start=\"5754\" data-end=\"5804\"\u003esleep architecture and slow-wave sleep signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5805\" data-end=\"5836\"\u003e\n\u003cp data-start=\"5807\" data-end=\"5836\"\u003ecircadian rhythm regulation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5837\" data-end=\"5874\"\u003e\n\u003cp data-start=\"5839\" data-end=\"5874\"\u003eneuroendocrine signaling pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5875\" data-end=\"5925\"\u003e\n\u003cp data-start=\"5877\" data-end=\"5925\"\u003eexcitatory–inhibitory neurotransmitter balance\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5926\" data-end=\"5963\"\u003e\n\u003cp data-start=\"5928\" data-end=\"5963\"\u003estress-associated neurophysiology\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"5964\" data-end=\"6009\"\u003e\n\u003cp data-start=\"5966\" data-end=\"6009\"\u003eoxidative stress and mitochondrial function\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eStructures:\u003c\/h3\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Delta_Sleep-Inducing_Peptide.png?v=1772706239\" alt=\"DSIP structure\" style=\"float: none;\"\u003e\u003c\/div\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/68816\"\u003eSource: PubChem\u003c\/a\u003e\u003c\/div\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cspan\u003eFor a detailed neurobiological discussion of sleep architecture, CSTC circuit dynamics, and experimental OCD-related pathways, see our in-depth research overview.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e→ \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/obsessive-compulsive-disorder-ocd-research\"\u003eOCD Circuit-Level Neurobiology Research\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch4 data-start=\"206\" data-end=\"254\"\u003eNeurotrophic Peptides in Cognitive Research\u003c\/h4\u003e\n\u003cp data-start=\"256\" data-end=\"471\"\u003eDSIP is frequently discussed in research exploring sleep, recovery, and cognitive function. Learn more about related compounds in our article: \u003ca href=\"https:\/\/www.peptideregenesis.com\/blogs\/peptide-blog\/neurotrophic-peptides-cognitive-research\"\u003e\u003cstrong data-start=\"399\" data-end=\"470\"\u003eBest Neurotrophic Peptides for Cognitive Research and Brain Support\u003c\/strong\u003e.\u003c\/a\u003e\u003c\/p\u003e","brand":"PRG","offers":[{"title":"Vial","offer_id":52641881882890,"sku":null,"price":130.0,"currency_code":"EUR","in_stock":true},{"title":"Pre-filled Pen ( 1 )","offer_id":52641881915658,"sku":null,"price":155.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/DSIP5mg_2.png?v=1772289664","url":"https:\/\/www.peptideregenesis.com\/products\/dsip-5mg","provider":"PRG","version":"1.0","type":"link"}