{"product_id":"cagrilintide-5mg","title":"Cagrilintide 5mg – Research Peptide","description":"\u003ch3 data-start=\"566\" data-end=\"600\"\u003eCagrilintide – Research Overview\u003c\/h3\u003e\n\u003cp data-start=\"602\" data-end=\"927\"\u003eCagrilintide is a long-acting amylin analog studied in experimental research for its interaction with appetite-related neuroendocrine signaling and metabolic regulation pathways. Laboratory studies frequently examine its role in satiety signaling, peptide hormone receptor pharmacology, and central energy-balance mechanisms.\u003c\/p\u003e\n\u003cp data-start=\"929\" data-end=\"1308\"\u003eCagrilintide (NNC0174-0833 \/ AM833) is a synthetic 37-amino-acid peptide derived from human amylin (islet amyloid polypeptide, IAPP). It has been engineered as a long-acting analog designed to interact with \u003cstrong data-start=\"1136\" data-end=\"1163\"\u003eamylin receptors (AMYR)\u003c\/strong\u003e and \u003cstrong data-start=\"1168\" data-end=\"1198\"\u003ecalcitonin receptors (CTR)\u003c\/strong\u003e, forming part of a class sometimes referred to as dual amylin receptor\/calcitonin receptor agonists (DACRAs).\u003c\/p\u003e\n\u003ch3 data-start=\"1315\" data-end=\"1345\"\u003eMolecular Mechanism Research\u003c\/h3\u003e\n\u003ch3 data-start=\"1347\" data-end=\"1392\"\u003eAmylin and Calcitonin Receptor Interaction\u003c\/h3\u003e\n\u003cp data-start=\"1394\" data-end=\"1700\"\u003eAmylin receptors consist of a \u003cstrong data-start=\"1424\" data-end=\"1512\"\u003ecalcitonin receptor core complexed with receptor activity-modifying proteins (RAMPs)\u003c\/strong\u003e. Cagrilintide has been shown in experimental models to activate these receptor complexes, producing intracellular signaling events associated with satiety-related neuroendocrine pathways.\u003c\/p\u003e\n\u003cp data-start=\"1702\" data-end=\"1808\"\u003eThese receptor systems are highly expressed in several regions involved in metabolic signaling, including:\u003c\/p\u003e\n\u003cul data-start=\"1810\" data-end=\"1936\"\u003e\n\u003cli data-start=\"1810\" data-end=\"1835\"\u003e\n\u003cp data-start=\"1812\" data-end=\"1835\"\u003ethe \u003cstrong data-start=\"1816\" data-end=\"1833\"\u003earea postrema\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1836\" data-end=\"1880\"\u003e\n\u003cp data-start=\"1838\" data-end=\"1880\"\u003ethe \u003cstrong data-start=\"1842\" data-end=\"1878\"\u003enucleus tractus solitarius (NTS)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1881\" data-end=\"1936\"\u003e\n\u003cp data-start=\"1883\" data-end=\"1936\"\u003ehypothalamic nuclei associated with energy regulation\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"1938\" data-end=\"2118\"\u003eActivation of these receptors has been associated in experimental models with modulation of neural circuits involved in satiety signaling and nutrient-responsive feedback pathways.\u003c\/p\u003e\n\u003ch3 data-start=\"2125\" data-end=\"2159\"\u003eCentral Neuroendocrine Signaling\u003c\/h3\u003e\n\u003cp data-start=\"2161\" data-end=\"2309\"\u003eIn preclinical research, cagrilintide has been examined for its influence on central nervous system signaling pathways that regulate energy balance.\u003c\/p\u003e\n\u003cp data-start=\"2311\" data-end=\"2421\"\u003eExperimental observations suggest receptor activation within brainstem and hypothalamic regions may influence:\u003c\/p\u003e\n\u003cul data-start=\"2423\" data-end=\"2548\"\u003e\n\u003cli data-start=\"2423\" data-end=\"2461\"\u003e\n\u003cp data-start=\"2425\" data-end=\"2461\"\u003esatiety-related neuronal signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2462\" data-end=\"2507\"\u003e\n\u003cp data-start=\"2464\" data-end=\"2507\"\u003ehypothalamic appetite regulation pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2508\" data-end=\"2548\"\u003e\n\u003cp data-start=\"2510\" data-end=\"2548\"\u003ereward-related food signaling circuits\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"2550\" data-end=\"2681\"\u003eThese neuroendocrine pathways are often studied in research investigating peptide hormone signaling involved in energy homeostasis.\u003c\/p\u003e\n\u003ch3 data-start=\"2688\" data-end=\"2719\"\u003ePeripheral Signaling Pathways\u003c\/h3\u003e\n\u003cp data-start=\"2721\" data-end=\"2861\"\u003eBeyond central receptor activity, experimental studies have also reported additional signaling events associated with cagrilintide activity.\u003c\/p\u003e\n\u003cp data-start=\"2863\" data-end=\"2877\"\u003eThese include:\u003c\/p\u003e\n\u003cul data-start=\"2879\" data-end=\"3050\"\u003e\n\u003cli data-start=\"2879\" data-end=\"2910\"\u003e\n\u003cp data-start=\"2881\" data-end=\"2910\"\u003e\u003cstrong data-start=\"2881\" data-end=\"2908\"\u003ecAMP signaling pathways\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2911\" data-end=\"2979\"\u003e\n\u003cp data-start=\"2913\" data-end=\"2979\"\u003ephosphorylation events involving cellular ion transport proteins\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"2980\" data-end=\"3050\"\u003e\n\u003cp data-start=\"2982\" data-end=\"3050\"\u003esignaling interactions observed in renal epithelial transport models\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-start=\"3052\" data-end=\"3186\"\u003eSuch observations are typically explored in preclinical studies examining peptide hormone signaling and metabolic regulatory pathways.\u003c\/p\u003e\n\u003ch3 data-start=\"3193\" data-end=\"3221\"\u003eStructural Characteristics\u003c\/h3\u003e\n\u003cp data-start=\"3223\" data-end=\"3451\"\u003eCagrilintide is a \u003cstrong data-start=\"3241\" data-end=\"3273\"\u003e37-amino-acid peptide analog\u003c\/strong\u003e derived from the endogenous amylin sequence. Structural modifications have been introduced to improve molecular stability and prolong receptor engagement in experimental models.\u003c\/p\u003e\n\u003cp data-start=\"3453\" data-end=\"3603\"\u003eThese modifications differentiate cagrilintide from earlier amylin analogs, which have also been used in research examining amylin receptor signaling.\u003c\/p\u003e\n\u003cp\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Cagrilintide.jpg?v=1770821612\"\u003e\u003c\/p\u003e\n\u003ch3\u003eProduct description:\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cspan\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e \u003c\/span\u003e\u003cspan\u003eC\u003csub\u003e194\u003c\/sub\u003eH\u003csub\u003e312\u003c\/sub\u003eN\u003csub\u003e54\u003c\/sub\u003eO\u003csub\u003e59\u003c\/sub\u003eS\u003csub\u003e2\u003c\/sub\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cspan\u003e\u003cstrong\u003eMolecular Weight: \u003c\/strong\u003e4409 g\/mol\u003c\/span\u003e\u003cspan\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cspan\u003e\u003cstrong\u003eCAS:\u003c\/strong\u003e \u003c\/span\u003e \u003cspan\u003e1415456-99-3\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cdiv class=\"text-left sm:table-cell sm:p-2 sm:border-t sm:border-gray-300 dark:sm:border-gray-300\/20 font-medium pt-1 sm:align-top sm:w-1\/3 xl:w-1\/4\"\u003e\n\u003cstrong data-start=\"847\" data-end=\"875\"\u003eTotal Active Ingredient:\u003c\/strong\u003e 5 mg per vial - ( Vial format: lyophilized powder for enhanced stability.)\u003cspan\u003e\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eStructures:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cdiv style=\"text-align: start;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Cagrilintide.png?v=1772704738\" alt=\"Cagrilintide structure\" style=\"margin-bottom: 16px; float: none;\"\u003e\u003c\/div\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/171397054#section=Structures\"\u003e\u003cspan\u003eSource: PubChem\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"PRG","offers":[{"title":"Vial","offer_id":52641876082954,"sku":null,"price":190.0,"currency_code":"EUR","in_stock":true},{"title":"Pre-filled Pen ( 1 )","offer_id":52641876115722,"sku":null,"price":215.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/Cagrilintide5mg_2.png?v=1772288882","url":"https:\/\/www.peptideregenesis.com\/products\/cagrilintide-5mg","provider":"PRG","version":"1.0","type":"link"}