{"product_id":"aod9604-10mg-fat-metabolism-metabolic-research-peptide","title":"AOD9604 10mg – Fat Metabolism \u0026 Metabolic Research Peptide","description":"\u003cp\u003e\u003cstrong\u003eAOD9604 Description\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAOD9604 is a synthetic peptide created from a specific fragment of the human growth hormone molecule.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt is studied for its ability to promote the breakdown of stored fat in the body. Unlike the full growth hormone, it does not stimulate growth or increase levels of IGF-1.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn fat cells, it activates processes that release fats for energy production while reducing the formation of new fat.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAnimal studies in obese models have shown reductions in body weight and fat accumulation with its administration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHuman clinical trials involving hundreds of overweight adults have demonstrated that it is safe and well tolerated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSome early trials reported modest reductions in body weight and abdominal fat.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLarger studies that included diet and exercise programs showed more variable results for weight loss.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eResearchers have also investigated its potential to support cartilage repair in joint disease models.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOverall, AOD9604 offers a targeted way to address fat metabolism and certain regenerative applications without the broader effects of complete growth hormone.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMolecular Mechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAOD9604, also known as the hexadecapeptide Tyr-hGH177-191, represents a precisely engineered fragment of the carboxyl terminus of human growth hormone (hGH), specifically residues 177 through 191 with an added N-terminal tyrosine residue for enhanced stability and oral bioavailability potential.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis structural modification isolates the lipolytic domain while eliminating the domains responsible for somatotropic, lactogenic, and diabetogenic activities inherent to the full-length 191-amino-acid hGH protein.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn the context of peptide research and synthesis, AOD9604 exemplifies a rational design strategy to dissect multifunctional proteins into bioactive minimal motifs, allowing selective modulation of adipose tissue metabolism without engaging the classical growth hormone receptor (GHR) signaling cascade that leads to JAK2\/STAT5 activation and subsequent IGF-1 transcription in hepatocytes and other tissues.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAt the biochemical level, this peptide maintains a compact conformation stabilized by a disulfide bridge between the two cysteine residues within its sequence, preserving key hydrophobic and charged motifs that interact with intracellular targets in adipocytes and hepatocytes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLipolysis and Fat Metabolism Pathways\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe molecular mechanism of action of AOD9604 centers on direct and selective enhancement of lipolysis coupled with potent inhibition of lipogenesis in white adipose tissue, operating largely independently of the somatotropic axis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn mature adipocytes, triglycerides stored in lipid droplets are hydrolyzed by hormone-sensitive lipase (HSL), the rate-limiting enzyme whose activity is tightly regulated by phosphorylation at multiple serine residues.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAOD9604 elevates intracellular cyclic AMP (cAMP) levels, likely through modulation of adenylate cyclase activity downstream of adrenergic signaling pathways, thereby activating protein kinase A (PKA).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePhosphorylated HSL translocates from the cytosol to the surface of lipid droplets, where it catalyzes the sequential cleavage of triglycerides into:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ediacylglycerol,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003emonoacylglycerol,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003efree fatty acids,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand glycerol.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eThis process is further amplified by upregulation of beta-3 adrenergic receptor (β3-AR) mRNA and protein expression specifically in obese adipose depots, where β3-AR levels are typically downregulated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eRestoration to levels observed in lean tissue heightens catecholamine sensitivity and sustains chronic lipolytic responsiveness without requiring direct agonism at the receptor itself.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAcute effects on energy expenditure and fatty acid oxidation persist even in β3-AR knockout models, indicating parallel or redundant pathways possibly involving direct modulation of mitochondrial β-oxidation enzymes or carnitine palmitoyltransferase-1 (CPT-1) facilitation via reduced malonyl-CoA inhibition.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnti-Lipogenic and Metabolic Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eConcomitantly, AOD9604 exerts anti-lipogenic effects by inhibiting acetyl-CoA carboxylase (ACC), the enzyme that carboxylates acetyl-CoA to form malonyl-CoA, the primary substrate for de novo fatty acid synthesis via fatty acid synthase (FAS) and the allosteric inhibitor of CPT-1.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLower malonyl-CoA concentrations relieve CPT-1 suppression at the outer mitochondrial membrane, channeling free fatty acids into β-oxidation rather than re-esterification or elongation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis dual lipolytic and anti-lipogenic profile mirrors a subset of hGH actions but occurs without GHR dimerization or downstream PI3K\/Akt\/mTOR engagement, explaining the absence of IGF-1 induction, muscle anabolism, or hepatic gluconeogenesis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn hepatocytes, similar ACC inhibition reduces very-low-density lipoprotein (VLDL) triglyceride output, contributing to improved circulating lipid profiles.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAt the cellular signaling level, AOD9604 induces a biphasic diacylglycerol (DAG) release that transiently activates protein kinase C (PKC) isoforms, further fine-tuning HSL trafficking and gene expression programs favoring oxidative metabolism over storage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThese mechanisms collectively shift adipocyte metabolism toward net fat mobilization, particularly in visceral depots prone to inflammation and ectopic lipid spillover in metabolic syndrome states.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eUnlike full-length hGH, which can induce insulin resistance via SOCS protein upregulation and JAK\/STAT-mediated interference with insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, AOD9604 preserves or may enhance insulin sensitivity by avoiding these feedback loops, as evidenced by maintained euglycemic clamp responses in chronic exposure models.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePotential Research Applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePotential research applications of AOD9604 extend beyond its original anti-obesity rationale to encompass regenerative applications in orthopedics and metabolic health, leveraging its tissue-selective actions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn obesity and associated dysmetabolism, the peptide’s ability to target visceral adipose tissue lipolysis without inducing hyperinsulinemia or hyperglycemia positions it as a candidate adjunct for research involving:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003ecentral adiposity,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003enon-alcoholic fatty liver disease (NAFLD),\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003edyslipidemia,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand type 2 diabetes risk.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eBy normalizing β3-AR expression in pathologically desensitized adipocytes, AOD9604 could restore endogenous catecholamine-driven fat mobilization, complementing lifestyle interventions that often fail to sustain visceral fat loss due to adaptive downregulation of lipolytic receptors.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn cartilage biology and osteoarthritis research, intra-articular delivery exploits potential chondroprotective and anabolic effects on synovial and cartilage extracellular matrix remodeling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePreclinical data indicate:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eenhanced proteoglycan synthesis,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ereduced matrix metalloproteinase activity,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand improved histological architecture in degenerative joints.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eThese effects may occur via localized modulation of inflammatory cytokine signaling or direct stimulation of chondrocyte survival pathways independent of systemic GH\/IGF-1.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis regenerative profile may extend to bone homeostasis, where osteoblast exposure to the peptide fragment stimulates proliferation and mineralized nodule formation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis offers utility in postmenopausal osteoporosis models characterized by cortical thinning and reduced bone mineral density.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCollectively, these applications highlight AOD9604 as a versatile tool in peptide-based regenerative and metabolic medicine, capitalizing on its minimal immunogenicity, rapid plasma clearance, and lack of endocrine disruption.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnimal Research Findings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAnimal trials have provided robust foundational evidence for these mechanisms and applications across multiple rodent and lagomorph models.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn genetically obese Zucker rats and ob\/ob mice, chronic systemic exposure to AOD9604 markedly attenuates excessive body weight gain — by over 50 percent relative to pair-fed controls in some cohorts — through elevated adipose tissue lipolytic rates measured as increased glycerol release ex vivo and heightened whole-body fat oxidation via indirect calorimetry.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThese effects correlate with restored β3-AR transcript levels in epididymal and retroperitoneal fat pads, normalizing the lipolytic deficit typical of leptin-resistant states, and occur without the insulin-desensitizing profile observed with equimolar intact hGH.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn β3-AR knockout mice, chronic administration fails to reduce body mass or enhance basal lipolysis, confirming the receptor’s permissive role in sustained adaptations, yet acute bolus dosing still augments energy expenditure and respiratory quotient shifts toward fat utilization, underscoring redundant signaling nodes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eToxicology assessments in Sprague-Dawley rats and cynomolgus monkeys at supratherapeutic multiples revealed:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eno genotoxicity,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eno organ histopathology,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eno immunogenicity,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand rapid proteolytic degradation consistent with short plasma half-life.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eCartilage and Bone Research Models\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAdditional regenerative models reinforce broader utility.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn collagenase-induced knee osteoarthritis in New Zealand white rabbits, repeated intra-articular injections of AOD9604 alone or combined with hyaluronic acid significantly improved:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003emacroscopic cartilage surface integrity,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ehistological OARSI scores,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ereduced fibrillation,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ereduced chondrocyte clustering,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ereduced proteoglycan loss,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand functional lameness indices.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eThese findings suggest matrix-preserving effects potentially mediated by decreased synovial inflammation or upregulated aggrecan and type II collagen expression in chondrocytes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn ovariectomized rat models of estrogen-deficient bone loss, systemic AOD9604 increased trabecular and cortical bone mineral density, elevated bone formation rates, and preserved biomechanical strength parameters such as ultimate load and stiffness.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThese actions are attributed to direct osteoblast mitogenic signaling without osteoclast activation or GH-mediated resorption coupling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThese preclinical outcomes collectively validate selective fat-mobilizing and tissue-reparative properties while highlighting favorable safety margins across species.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHuman Clinical Research Findings\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHuman clinical development encompassed six randomized, double-blind, placebo-controlled trials conducted between 2001 and 2006, enrolling approximately 900 clinically obese adults alongside smaller cohorts of healthy volunteers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe program progressed from single-dose intravenous and oral pilot studies through short-term multiple-dose evaluations to two pivotal longer-term oral Phase II protocols:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eone 12-week study in roughly 300 participants,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand one 24-week study in over 500 subjects that incorporated standardized diet and exercise counseling.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eAcross all protocols, AOD9604 exhibited an adverse event profile statistically indistinguishable from placebo, with mild-to-moderate headaches, transient gastrointestinal discomfort, or upper respiratory symptoms occurring at comparable frequencies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNo treatment-related serious adverse events, withdrawals, or clinically meaningful alterations in vital signs, electrocardiography, hematology, or serum chemistry were reported.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNotably, no increases in circulating IGF-1, perturbations in fasting glucose, insulin, or oral glucose tolerance test parameters, or development of anti-peptide antibodies were detected.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis confirms the absence of somatotropic spillover and supports metabolic neutrality.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eEarly efficacy signals included modest body weight decrements and preferential abdominal fat reduction assessed by dual-energy X-ray absorptiometry or waist circumference.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHowever, the larger lifestyle-enriched 24-week trial failed to demonstrate statistically superior weight or fat mass loss relative to placebo plus diet and exercise, leading to discontinuation of further obesity-focused development around 2007 despite the consistently benign safety database.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSubsequent analyses have revisited the dataset for subgroup signals in visceral adiposity responders and have prompted exploratory investigations into intra-articular applications for osteoarthritis, where the peptide’s localized regenerative potential remains under active preclinical-to-early-clinical translation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSummary\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn summary, AOD9604 embodies a successful example of domain-specific peptide engineering that decouples beneficial lipid metabolic reprogramming from the broader effects of parent human growth hormone.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIts molecular actions center on:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eHSL activation,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eACC inhibition,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eβ3-AR sensitization,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCPT-1 derepression,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003efat mobilization,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand cartilage-associated regenerative signaling.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eThese mechanisms drive net adipose catabolism while preserving insulin sensitivity and avoiding endocrine feedback.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePreclinical models support applications in:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eobesity-related fat redistribution,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ejoint cartilage preservation,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eskeletal maintenance,\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eand metabolic research.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eHuman experience underscores exceptional tolerability across nearly a thousand exposures.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAlthough larger-scale weight-loss efficacy proved context-dependent, the peptide’s clean pharmacological footprint and emerging regenerative data sustain interest within specialized peptide research for targeted metabolic and orthopedic applications.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOngoing synthesis optimization and formulation strategies may further unlock its utility in these domains.\u003c\/span\u003e\u003c\/p\u003e","brand":"PRG","offers":[{"title":"Pre-filled Pen","offer_id":53119473254666,"sku":null,"price":165.0,"currency_code":"EUR","in_stock":true},{"title":"Vial","offer_id":53119473287434,"sku":null,"price":140.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0908\/7113\/6522\/files\/aod_2.png?v=1779960930","url":"https:\/\/www.peptideregenesis.com\/it\/products\/aod9604-10mg-fat-metabolism-metabolic-research-peptide","provider":"PRG","version":"1.0","type":"link"}